ID   M059K
AC   CVCL_0401
DR   CLO; CLO_0007446
DR   EFO; EFO_0006451
DR   MCCL; MCC:0000295
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-2365
DR   BCRC; 60381
DR   BioSample; SAMN03473046
DR   BioSample; SAMN10987790
DR   CCLE; M059K_CENTRAL_NERVOUS_SYSTEM
DR   Cell_Model_Passport; SIDM00639
DR   Cosmic; 897445
DR   Cosmic; 1237543
DR   DepMap; ACH-000152
DR   GEO; GSM887286
DR   GEO; GSM888361
DR   GEO; GSM1374641
DR   GEO; GSM1670071
DR   IARC_TP53; 28272
DR   LiGeA; CCLE_918
DR   LINCS_LDP; LCL-1362
DR   PharmacoDB; M059K_878_2019
DR   Wikidata; Q54903416
RX   PubMed=7494872;
RX   PubMed=8316628;
RX   PubMed=10629611;
RX   PubMed=11023613;
RX   PubMed=12105990;
RX   PubMed=18077418;
RX   PubMed=21406405;
RX   PubMed=22460905;
RX   PubMed=25485619;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Characteristics: Radioresistant (PubMed=7494872).
CC   Sequence variation: Homozygous for PTEN p.Pro204fs*17 (c.610delC) (CCLE).
CC   Sequence variation: Homozygous for TP53 p.Glu286lys (c.856G>A) (PubMed=11023613; CCLE).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative phosphoproteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.16%; Native American=0%; East Asian, North=2.3%; East Asian, South=0%; South Asian=0%; European, North=69.38%; European, South=28.16% (PubMed=30894373).
ST   Source(s): ATCC; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 14
ST   D16S539: 10,12
ST   D18S51: 15,19
ST   D21S11: 30,31.2
ST   D3S1358: 14,15
ST   D5S818: 11,12
ST   D7S820: 10
ST   D8S1179: 15
ST   FGA: 20,26
ST   Penta D: 12,13
ST   Penta E: 7,15
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens
OI   CVCL_0400 ! M059J
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 12-03-20; Version: 23
//
RX   PubMed=7494872; DOI=10.2307/3578948;
RA   Allalunis-Turner M.J., Zia P.K.Y., Barron G.M., Mirzayans R.,
RA   Day R.S. III;
RT   "Radiation-induced DNA damage and repair in cells of a radiosensitive
RT   human malignant glioma cell line.";
RL   Radiat. Res. 144:288-293(1995).
//
RX   PubMed=8316628; DOI=10.2307/3578196;
RA   Allalunis-Turner M.J., Barron G.M., Day R.S. III, Dobler K.D.,
RA   Mirzayans R.;
RT   "Isolation of two cell lines from a human malignant glioma specimen
RT   differing in sensitivity to radiation and chemotherapeutic drugs.";
RL   Radiat. Res. 134:349-354(1993).
//
RX   PubMed=10629611; DOI=10.1667/0033-7587(2000)153[0125:COTRMC]2.0.CO;2;
RA   Hoppe B.S., Jensen R.B., Kirchgessner C.U.;
RT   "Complementation of the radiosensitive M059J cell line.";
RL   Radiat. Res. 153:125-130(2000).
//
RX   PubMed=11023613; DOI=10.1667/0033-7587(2000)154[0473:HTFTMG]2.0.CO;2;
RA   Anderson C.W., Allalunis-Turner M.J.;
RT   "Human TP53 from the malignant glioma-derived cell lines M059J and
RT   M059K has a cancer-associated mutation in exon 8.";
RL   Radiat. Res. 154:473-476(2000).
//
RX   PubMed=12105990; DOI=10.1667/0033-7587(2002)158[0195:DOAGMI]2.0.CO;2;
RA   Tsuchida R., Yamada T., Takagi M., Shimada A., Ishioka C., Katsuki Y.,
RA   Igarashi T., Chessa L., Delia D., Teraoka H., Mizutani S.;
RT   "Detection of ATM gene mutation in human glioma cell line M059J by a
RT   rapid frameshift/stop codon assay in yeast.";
RL   Radiat. Res. 158:195-201(2002).
//
RX   PubMed=18077418; DOI=10.1073/pnas.0707579104;
RA   Stokes M.P., Rush J., Macneill J., Ren J.M., Sprott K., Nardone J.,
RA   Yang V., Beausoleil S.A., Gygi S.P., Livingstone M., Zhang H.,
RA   Polakiewicz R.D., Comb M.J.;
RT   "Profiling of UV-induced ATM/ATR signaling pathways.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:19855-19860(2007).
//
RX   PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112;
RA   Grzmil M., Morin P. Jr., Lino M.M., Merlo A., Frank S., Wang Y.,
RA   Moncayo G., Hemmings B.A.;
RT   "MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta
RT   signaling pathway in human glioblastoma.";
RL   Cancer Res. 71:2392-2402(2011).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//