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Cellosaurus MCF-7/2a (CVCL_0412)

[Text version]
Cell line name MCF-7/2a
Synonyms MCF-7/2A; MCF7/2a; MCF-7 clone 2A
Accession CVCL_0412
Resource Identification Initiative To cite this cell line use: MCF-7/2a (RRID:CVCL_0412)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:29063; L-mimosine.
Caution: There is confusion in the literature between estrogen-independent MCF-7:2A (Cellosaurus=CVCL_4Y53), L-mimosine-resistant MCF-7/2a (Cellosaurus=CVCL_0412) and EREwtcluc transfected MCF-7-2a (Cellosaurus=CVCL_4Y54).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=10766749; DOI=10.1074/jbc.M001610200
Oppenheim E.W., Nasrallah I.M., Mastri M.G., Stover P.J.
Mimosine is a cell-specific antagonist of folate metabolism.
J. Biol. Chem. 275:19268-19274(2000)

PubMed=15531579; DOI=10.1074/jbc.M410467200
Perry C., Sastry R., Nasrallah I.M., Stover P.J.
Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication.
J. Biol. Chem. 280:396-400(2005)

Cross-references
Cell line databases/resources MCCL; MCC:0000308
cancercelllines; CVCL_0412
Anatomy/cell type resources BTO; BTO:0002270
Encyclopedic resources Wikidata; Q54904345
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22