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Cellosaurus MCF7mp53 (CVCL_0415)

[Text version]
Cell line name MCF7mp53
Synonyms MCF7 mp53; MCF-7-mp53; MCF-7mp53
Accession CVCL_0415
Resource Identification Initiative To cite this cell line use: MCF7mp53 (RRID:CVCL_0415)
Comments Population: Caucasian.
Transfected with: HGNC; 11998; TP53.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=11278253; DOI=10.1074/jbc.C100025200
Gupta S., Radha V., Furukawa Y., Swarup G.
Direct transcriptional activation of human caspase-1 by tumor suppressor p53.
J. Biol. Chem. 276:10585-10588(2001)

Cross-references
Cell line databases/resources MCCL; MCC:0000311
cancercelllines; CVCL_0415
Encyclopedic resources Wikidata; Q54904475
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number19