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Cellosaurus MDCK (CVCL_0422)

Cell line name MDCK
Synonyms MDCK (NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney
Accession CVCL_0422
Resource Identification Initiative To cite this cell line use: MDCK (RRID:CVCL_0422)
Comments Group: Vaccine production cell line.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Caution: There seems to be two distinct cell lines which were assigned NCBI_Iran catalog number C426.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Children:
CVCL_4164 (DoCl1 (S+L-))CVCL_GY95 (Luc9.1)CVCL_2A36 (MDCK 33016)
CVCL_DF69 (MDCK 9B9-1B1)CVCL_DF70 (MDCK 9B9-1E4)CVCL_AP67 (MDCK Sky1023)
CVCL_AP68 (MDCK Sky10234)CVCL_AP69 (MDCK Sky3851)CVCL_V359 (MDCK Tet-Off)
CVCL_K177 (MDCK-AD)CVCL_AP66 (MDCK-B-702)CVCL_AP70 (MDCK-C11)
CVCL_0423 (MDCK-C7)CVCL_DF31 (MDCK-chAbcb1)CVCL_AQ31 (MDCK-E [Korea])
CVCL_Y089 (MDCK-E [Taiwan])CVCL_AP75 (MDCK-F)CVCL_0592 (MDCK-I)
CVCL_0424 (MDCK-II)CVCL_IZ19 (MDCK-P-gp)CVCL_JX35 (MDCK-Protein Free)
CVCL_IQ72 (MDCK-S)CVCL_IQ73 (MDCK-SF101)CVCL_IQ74 (MDCK-SF102)
CVCL_IQ75 (MDCK-SF103)CVCL_Z936 (MDCK-SIAT1)CVCL_B033 (MDCK.1)
CVCL_B034 (MDCK.2)CVCL_DE56 (MDCK.5F1)CVCL_2586 (MDCK.P3)
CVCL_K241 (MDCK/60)CVCL_6452 (Super Dome)CVCL_6453 (Super Tube)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages https://en.wikipedia.org/wiki/Madin-Darby_Canine_Kidney_Cells
https://www.atcc.org/support/faqs/5889f/Morphology%20of%20ATCC%20CCL34%20MDCK-444.aspx
https://www.phe-culturecollections.org.uk/media/137096/mcdk-cell-line-profile.pdf
http://micro.magnet.fsu.edu/primer/techniques/fluorescence/gallery/cells/mdck/mdckcells.html
http://en.vircell.com/products/mdck-cell-line/
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-89.html
Publications

PubMed=13901412; DOI=10.1126/science.138.3536.42
Green I.J.
Serial propagation of influenza B (Lee) virus in a transmissible line of canine kidney cells.
Science 138:42-43(1962)

PubMed=5918973; DOI=10.3181/00379727-122-31293
Gaush C.R., Hard W.L., Smith T.F.
Characterization of an established line of canine kidney cells (MDCK).
Proc. Soc. Exp. Biol. Med. 122:931-935(1966)

PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022
Karger A., Bettin B., Lenk M., Mettenleiter T.C.
Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing.
J. Virol. Methods 164:116-121(2010)

PubMed=21819694
Omeir R.L., Teferedegne B., Foseh G.S., Beren J.J., Snoy P.J., Brinster L.R., Cook J.L., Peden K., Lewis A.M. Jr.
Heterogeneity of the tumorigenic phenotype expressed by Madin-Darby canine kidney cells.
Comp. Med. 61:243-250(2011)

PubMed=21982418; DOI=10.1186/1471-2121-12-43
Dukes J.D., Whitley P., Chalmers A.D.
The MDCK variety pack: choosing the right strain.
BMC Cell Biol. 12:43-43(2011)

PubMed=24058646; DOI=10.1371/journal.pone.0075014
Lugovtsev V.Y., Melnyk D., Weir J.P.
Heterogeneity of the MDCK cell line and its applicability for influenza virus research.
PLoS ONE 8:E75014-E75014(2013)

PubMed=25903999; DOI=10.1002/biot.201400388
Genzel Y.
Designing cell lines for viral vaccine production: where do we stand?
Biotechnol. J. 10:728-740(2015)

Cross-references
Cell line collections AddexBio; P0014003/4928
ATCC; CCL-34
ATCC; CRL-6253 - Discontinued
BCRC; 60004
BCRJ; 0168
BEI_Resources; NR-2628
CCLV; CCLV-RIE 0083
CLS; 602280/p823_MDCK_(NBL-2)
ECACC; 84121903
ECACC; 85011435
IZSLER; BS CL 64
JCRB; IFO50071
JCRB; JCRB9029
KCB; KCB 2006105YJ
KCLB; 10034
NCBI_Iran; C426
RCB; RCB0995
Cell line databases/resources CLDB; cl3417
CLDB; cl3418
CLDB; cl3419
CLDB; cl3420
CLDB; cl3421
CLDB; cl3422
CLDB; cl3423
CLDB; cl3424
CLDB; cl3425
CCRID; 3111C0001CCC000078
CCRID; 3111C0002000000045
CCRID; 3131C0001000400014
CCRID; 3131C0001000400024
CCRID; 3142C0001000000012
CCRID; 3142C0001000000149
Lonza; 153
TOKU-E; 2403
TOKU-E; 3636
Ontologies BTO; BTO:0000837
CLO; CLO_0007646
CLO; CLO_0007647
CLO; CLO_0050861
MCCL; MCC:0000319
MeSH; D061985
Chemistry resources ChEMBL-Cells; CHEMBL3308370
ChEMBL-Targets; CHEMBL614068
Other Wikidata; Q28335011