ID   MDCK
AC   CVCL_0422
SY   MDCK (NBL-2); MDCK(NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney
DR   BTO; BTO:0000837
DR   CLO; CLO_0007646
DR   CLO; CLO_0007647
DR   CLO; CLO_0050861
DR   MCCL; MCC:0000319
DR   CLDB; cl3417
DR   CLDB; cl3418
DR   CLDB; cl3419
DR   CLDB; cl3420
DR   CLDB; cl3421
DR   CLDB; cl3422
DR   CLDB; cl3423
DR   CLDB; cl3424
DR   CLDB; cl3425
DR   AddexBio; P0014003/4928
DR   ATCC; CCL-34
DR   ATCC; CRL-6253
DR   BCRC; 60004
DR   BCRJ; 0168
DR   BEI_Resources; NR-2628
DR   CCLV; CCLV-RIE 0083
DR   CCRID; 1101CAN-PUMC000078
DR   CCRID; 1102CAN-NIFDC00045
DR   CCRID; 3101CANGNO23
DR   CCRID; 4201CAN-CCTCC00012
DR   CCTCC; GDC0012
DR   CCTCC; GDC0401
DR   ChEMBL-Cells; CHEMBL3308370
DR   ChEMBL-Targets; CHEMBL614068
DR   CLS; 602280
DR   ECACC; 84121903
DR   ECACC; 85011435
DR   FCS-free; 41-14-47-1-8-9
DR   FCS-free; 41-14-321-2-3-3
DR   FCS-free; 41-14-427-1-4-3
DR   FCS-free; 41-14-585-1-18-2
DR   FCS-free; 41-14-587-1-18-2
DR   FCS-free; 41-14-588-2-18-2
DR   GEO; GSM4009056
DR   GEO; GSM4009057
DR   GEO; GSM4009058
DR   IBRC; C10556
DR   IZSLER; BS CL 64
DR   JCRB; IFO50071
DR   JCRB; JCRB9029
DR   KCB; KCB 2006105YJ
DR   KCLB; 10034
DR   Lonza; 153
DR   MeSH; D061985
DR   NCBI_Iran; C426
DR   PRIDE; PXD014768
DR   PRIDE; PXD024031
DR   PubChem_Cell_line; CVCL_0422
DR   RCB; RCB0995
DR   TOKU-E; 2403
DR   TOKU-E; 3636
DR   Ubigene; YC-C005
DR   Wikidata; Q28335011
RX   DOI=10.1007/BF02618370;
RX   PubMed=222773;
RX   PubMed=5918973;
RX   PubMed=6480288;
RX   PubMed=12667817;
RX   PubMed=13901412;
RX   PubMed=19941903;
RX   PubMed=21819694;
RX   PubMed=21982418;
RX   PubMed=24058646;
RX   PubMed=25903999;
RX   PubMed=33122286;
RX   PubMed=33389257;
WW   https://en.wikipedia.org/wiki/Madin-Darby_Canine_Kidney_Cells
WW   https://www.atcc.org/en/support/technical-support/faqs/morphology-of-atcc-ccl-34-mdck
WW   https://www.phe-culturecollections.org.uk/media/137096/mcdk-cell-line-profile.pdf
WW   https://micro.magnet.fsu.edu/primer/techniques/fluorescence/gallery/cells/mdck/mdckcells.html
WW   https://www.olympus-lifescience.com/de/microscope-resource/primer/techniques/fluorescence/gallery/cells/epithelialindex/
WW   https://en.vircell.com/products/mdck-cell-line/
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-89.html
CC   Group: Vaccine production cell line.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Characteristics: Used for virus production for vaccine development, toxicology and industrial biotechnology research, and high-throughput screening (ATCC=CCL-34).
CC   Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Caution: There seem to be two distinct cell lines which were assigned NCBI_Iran catalog number C426.
CC   Discontinued: ATCC; CRL-6253; true.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Cocker Spaniel.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 37
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=222773; DOI=10.1083/jcb.81.3.635;
RA   Rindler M.J., Chuman L.M., Shaffer L., Saier M.H. Jr.;
RT   "Retention of differentiated properties in an established dog kidney
RT   epithelial cell line (MDCK).";
RL   J. Cell Biol. 81:635-648(1979).
//
RX   PubMed=5918973; DOI=10.3181/00379727-122-31293;
RA   Gaush C.R., Hard W.L., Smith T.F.;
RT   "Characterization of an established line of canine kidney cells
RT   (MDCK).";
RL   Proc. Soc. Exp. Biol. Med. 122:931-935(1966).
//
RX   PubMed=6480288;
RA   Schroyens W., Bruyneel R., Tchao R., Leighton J., Dragonetti C.,
RA   Mareel M.M.;
RT   "Comparison of invasiveness and non-invasiveness of two epithelial
RT   cell lines in vitro.";
RL   Invasion Metastasis 4:160-170(1984).
//
RX   PubMed=12667817; DOI=10.1016/S0042-6822(02)00064-8;
RA   Romanova J., Katinger D., Ferko B., Voglauer R., Mochalova L.,
RA   Bovin N., Lim W., Katinger H., Egorov A.;
RT   "Distinct host range of influenza H3N2 virus isolates in Vero and MDCK
RT   cells is determined by cell specific glycosylation pattern.";
RL   Virology 307:90-97(2003).
//
RX   PubMed=13901412; DOI=10.1126/science.138.3536.42;
RA   Green I.J.;
RT   "Serial propagation of influenza B (Lee) virus in a transmissible line
RT   of canine kidney cells.";
RL   Science 138:42-43(1962).
//
RX   PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022;
RA   Karger A., Bettin B., Lenk M., Mettenleiter T.C.;
RT   "Rapid characterisation of cell cultures by matrix-assisted laser
RT   desorption/ionisation mass spectrometric typing.";
RL   J. Virol. Methods 164:116-121(2010).
//
RX   PubMed=21819694;
RA   Omeir R.L., Teferedegne B., Foseh G.S., Beren J.J., Snoy P.J.,
RA   Brinster L.R., Cook J.L., Peden K., Lewis A.M. Jr.;
RT   "Heterogeneity of the tumorigenic phenotype expressed by Madin-Darby
RT   canine kidney cells.";
RL   Comp. Med. 61:243-250(2011).
//
RX   PubMed=21982418; DOI=10.1186/1471-2121-12-43;
RA   Dukes J.D., Whitley P., Chalmers A.D.;
RT   "The MDCK variety pack: choosing the right strain.";
RL   BMC Cell Biol. 12:43.1-43.4(2011).
//
RX   PubMed=24058646; DOI=10.1371/journal.pone.0075014;
RA   Lugovtsev V.Y., Melnyk D., Weir J.P.;
RT   "Heterogeneity of the MDCK cell line and its applicability for
RT   influenza virus research.";
RL   PLoS ONE 8:E75014-E75014(2013).
//
RX   PubMed=25903999; DOI=10.1002/biot.201400388;
RA   Genzel Y.;
RT   "Designing cell lines for viral vaccine production: where do we
RT   stand?";
RL   Biotechnol. J. 10:728-740(2015).
//
RX   PubMed=33122286; DOI=10.1681/ASN.2020010009;
RA   Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.;
RT   "Transcriptomes of major proximal tubule cell culture models.";
RL   J. Am. Soc. Nephrol. 32:86-97(2021).
//
RX   PubMed=33389257; DOI=10.1007/s10096-020-04106-0;
RA   Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.;
RT   "Culture of SARS-CoV-2 in a panel of laboratory cell lines,
RT   permissivity, and differences in growth profile.";
RL   Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021).
//