AC   CVCL_0424
DR   BTO; BTO:0004607
DR   MCCL; MCC:0000321
DR   AddexBio; P0014001/82
DR   ChEMBL-Cells; CHEMBL3308862
DR   ECACC; 00062107
DR   Lonza; 811
DR   PRIDE; PXD001130
DR   RCB; RCB5148
DR   Wikidata; Q54904781
RX   PubMed=1468552;
RX   PubMed=19941903;
RX   PubMed=21766308;
RX   PubMed=21982418;
RX   PubMed=24975811;
CC   Group: Vaccine production cell line.
CC   Omics: Deep proteome analysis.
CC   Derived from sampling site: Kidney.
CC   Breed/subspecies: Cocker Spaniel.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris
HI   CVCL_0422 ! MDCK
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 17
RX   PubMed=1468552; DOI=10.1016/0014-5793(92)81476-3;
RA   Grunberg J., Luginbuhl U., Sterchi E.E.;
RT   "Proteolytic processing of human intestinal lactase-phlorizin
RT   hydrolase precursor is not a prerequisite for correct sorting in
RT   Madin Darby canine kidney (MDCK) cells.";
RL   FEBS Lett. 314:224-228(1992).
RX   PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022;
RA   Karger A., Bettin B., Lenk M., Mettenleiter T.C.;
RT   "Rapid characterisation of cell cultures by matrix-assisted laser
RT   desorption/ionisation mass spectrometric typing.";
RL   J. Virol. Methods 164:116-121(2010).
RX   PubMed=21766308; DOI=10.1002/jps.22674;
RA   Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X.,
RA   Gebhard D.F., Lai Y., Federico J.J. III, Davidson R.E., Smith R.,
RA   Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S.,
RA   Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.;
RT   "Development of a new permeability assay using low-efflux MDCKII
RT   cells.";
RL   J. Pharm. Sci. 100:4974-4985(2011).
RX   PubMed=21982418; DOI=10.1186/1471-2121-12-43;
RA   Dukes J.D., Whitley P., Chalmers A.D.;
RT   "The MDCK variety pack: choosing the right strain.";
RL   BMC Cell Biol. 12:43.1-43.4(2011).
RX   PubMed=24975811; DOI=10.1016/j.vaccine.2014.06.045;
RA   Donis R.O., Chen I.-M., Davis C.T., Foust A., Hossain M.J.,
RA   Johnson A., Klimov A., Loughlin R., Xu X., Tsai T., Blayer S.,
RA   Trusheim H., Colegate T., Fox J., Taylor B., Hussain A., Barr I.,
RA   Baas C., Louwerens J., Geuns E., Lee M.-S., Venhuizen O., Neumeier E.,
RA   Ziegler T.;
RT   "Performance characteristics of qualified cell lines for isolation and
RT   propagation of influenza viruses for vaccine manufacturing.";
RL   Vaccine 32:6583-6590(2014).