Cell line name | MG-63 | ||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Synonyms | M-G63; MG63 | ||||||||||||||||||||||||||||||||||||||
Accession | CVCL_0426 | ||||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: MG-63 (RRID:CVCL_0426) | ||||||||||||||||||||||||||||||||||||||
Comments | Group: Space-flown cell line (cellonaut). Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: MD Anderson Cell Lines Project. Population: Caucasian. Characteristics: Can be induced to differentiate by treating the cells with 1,25-dihydroxyvitamin D3 and TGF-beta. The cells do not differentiate into the mineralized state, but stop at the matrix maturation stage (PubMed=1577731). Doubling time: 38 hours (PubMed=218153); 28.3 hours (PubMed=19363654). Microsatellite instability: Stable (MSS) (Sanger). Omics: Array-based CGH. Omics: CNV analysis. Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: H3K4me1 ChIP-seq epigenome analysis. Omics: H3K27ac ChIP-seq epigenome analysis. Omics: Metabolome analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis. Anecdotal: Have been flown in space on Foton-10 and Foton-M3 to study if differentiation is altered in microgravity (PubMed=9144345; PubMed=9600771, PubMed=24903274). Caution: The reported STR profile from CLS of this cell line was changed in June 2019. Seven conflicts with other sources were resolved. Misspelling: MGG3; In figure 4 of PubMed=2823272. | ||||||||||||||||||||||||||||||||||||||
Sequence variations | Gene deletion; CDKN2A; Zygosity=Homozygous (PubMed=19787792; ATCC).Mutation; TP53; none detected (PubMed=19787792). | ||||||||||||||||||||||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
| ||||||||||||||||||||||||||||||||||||||
Disease | Osteosarcoma (NCIt: C9145) Osteosarcoma (ORDO: Orphanet_668) Derived from metastatic site: Bone; left femur. | ||||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
| ||||||||||||||||||||||||||||||||||||||
Hierarchy | Children:
| ||||||||||||||||||||||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||||||||||||||||||||||
Age at sampling | 14Y | ||||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; ECACC; JCRB; KCLB; PubMed=19787792; PubMed=25877200; RCB; TKG Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||||
Web pages | http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-91.html http://tcpaportal.org/mclp/ http://www.cellresource.cn/fdetail.aspx?id=80 http://www.cellresource.cn/fdetail.aspx?id=692 http://www.cellresource.cn/fdetail.aspx?id=841 | ||||||||||||||||||||||||||||||||||||||
Publications | PubMed=883813; DOI=10.1128/AAC.12.1.11 PubMed=218153; DOI=10.1159/000225298 PubMed=2823272; DOI=10.1073/pnas.84.21.7716 PubMed=1577731 PubMed=7873286; DOI=10.1016/8756-3282(94)90305-0 PubMed=8617485; DOI=10.1016/S0046-8177(96)90115-X PubMed=9144345; DOI=10.1359/jbmr.1997.12.5.786 PubMed=9600771; DOI=10.1016/S8756-3282(98)00007-6 PubMed=12645653; DOI=10.1016/S0165-4608(02)00685-4 PubMed=15736406 PubMed=19160414; DOI=10.1002/jcp.21667 PubMed=19363654; DOI=10.1007/s10585-009-9259-6 PubMed=19787792; DOI=10.1002/gcc.20717 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=21519327; DOI=10.1038/labinvest.2011.72 PubMed=22460905; DOI=10.1038/nature11003 PubMed=23129384; DOI=10.1002/jcp.24272 PubMed=24903274; DOI=10.1096/fj.14-249714 PubMed=25382592; DOI=10.1021/pr500907d PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=26320182; DOI=10.18632/oncotarget.5177 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 PubMed=29334376; DOI=10.1038/nm.4475 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 | ||||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||||
Cell line collections | AddexBio; C0004007/4991
ATCC; CRL-1427 BCRC; 60279 BCRJ; 0173 CCTCC; GDC0074 CLS; 300441/p2938_MG-63 ECACC; 86051601 ICLC; HTL99003 IZSLER; BS TCL 40 JCRB; IFO50108 KCB; KCB 200528YJ KCLB; 21427 NCBI_Iran; C555 RCB; RCB1890 TKG; TKG 0294 | ||||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl3462
CLDB; cl3463 CLDB; cl3464 CLDB; cl3465 CLDB; cl4934 CCLE; MG63_BONE CCRID; 3111C0001CCC000080 CCRID; 3131C0001000700124 CCRID; 3142C0001000000073 Cell_Model_Passport; SIDM00525 Cosmic-CLP; 908131 DepMap; ACH-000359 IGRhCellID; MG63 LINCS_LDP; LCL-1428 Lonza; 872 TOKU-E; 2429 | ||||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0001596
CLO; CLO_0007699 CLO; CLO_0007701 CLO; CLO_0050808 EFO; EFO_0002234 MCCL; MCC:0000323 | ||||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03471910
BioSample; SAMN03472771 BioSample; SAMN10988146 ENCODE; ENCBS091SUW ENCODE; ENCBS462PMF | ||||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308498
ChEMBL-Targets; CHEMBL614347 GDSC; 908131 PharmacoDB; MG63_924_2019 | ||||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783 ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 GEO; GSM170251 GEO; GSM320828 GEO; GSM827317 GEO; GSM879217 GEO; GSM887314 GEO; GSM888390 GEO; GSM1670103 GEO; GSM1915004 GEO; GSM1915005 GEO; GSM1915006 GEO; GSM1915007 GEO; GSM2635311 GEO; GSM2635312 GEO; GSM1915033 GEO; GSM1915034 | ||||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q54905408 | ||||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 755310
Cosmic; 908131 Cosmic; 931036 Cosmic; 931913 Cosmic; 1044085 Cosmic; 1070844 Cosmic; 1074394 Cosmic; 1082504 Cosmic; 1188475 Cosmic; 1529903 IARC_TP53; 21498 IARC_TP53; 21660 LiGeA; CCLE_145 Progenetix; CVCL_0426 | ||||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||||||||
Version number | 34 |