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Cellosaurus MIN6 (CVCL_0431)

[Text version]

Cell line name MIN6
Synonyms Min6; MIN-6; Mouse INsulinoma 6
Accession CVCL_0431
Resource Identification Initiative To cite this cell line use: MIN6 (RRID:CVCL_0431)
Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Cell surface proteome.
Omics: Endoplasmic reticulum proteome analysis.
Derived from sampling site: Pancreas; islets of Langerhans; beta cells.
Disease Mouse insulinoma (NCIt: C34053)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 IT6 transgenic.
Hierarchy Children:
CVCL_A7QH (MIN6 rho0)CVCL_A8QH (MIN6-cl4)CVCL_4372 (MIN6-m14)
CVCL_4371 (MIN6-m9)CVCL_D686 (MIN6N8)
Sex of cell Sex unspecified
Age at sampling 13W
Category Transformed cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-93.html

PubMed=2163307; DOI=10.1210/endo-127-1-126
Miyazaki J.-I., Araki K., Yamato E., Ikegami H., Asano T., Shibasaki Y., Oka Y., Yamamura K.-I.
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms.
Endocrinology 127:126-132(1990)

Poitout V., Olson L.K., Robertson R.P.
Insulin-secreting cell lines: classification, characteristics and potential applications.
Diabetes Metab. 22:7-14(1996)

PubMed=8824267; DOI=10.1074/jbc.271.42.26194
Soejima A., Inoue K., Takai D., Kaneko M., Ishihara H., Oka Y., Hayashi J.-I.
Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6.
J. Biol. Chem. 271:26194-26199(1996)

PubMed=18845907; DOI=10.1507/endocrj.K08E-172
Nakashima K., Kanda Y., Hirokawa Y., Kawasaki F., Matsuki M., Kaku K.
MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones.
Endocr. J. 56:45-53(2009)

PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=22808281; DOI=10.1371/journal.pone.0040868
Cheng K., Delghingaro-Augusto V., Nolan C.J., Turner N., Hallahan N., Andrikopoulos S., Gunton J.E.
High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.
PLoS ONE 7:E40868-E40868(2012)

PubMed=23560115; DOI=10.1371/journal.pone.0061211
Yamato E., Tashiro F., Miyazaki J.-I.
Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic beta cell line MIN6.
PLoS ONE 8:E61211-E61211(2013)

PubMed=25546123; DOI=10.1002/pmic.201400345
Lee J.-S., Wu Y., Schnepp P., Fang J., Zhang X., Karnovsky A., Woods J., Stemmer P.M., Liu M., Zhang K., Chen X.
Proteomics analysis of rough endoplasmic reticulum in pancreatic beta cells.
Proteomics 15:1508-1511(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

Cell line collections AddexBio; C0018008/403
BCRJ; 0293
IBRC; C10524
Cell line databases/resources Lonza; 163
Ontologies BTO; BTO:0002284
EFO; EFO_0002829
MCCL; MCC:0000326
Other Wikidata; Q12513178
Proteomic databases PRIDE; PXD000589
PRIDE; PXD001081
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number20