ID   MIN6
AC   CVCL_0431
SY   Min6; MIN-6; Mouse INsulinoma 6
DR   BTO; BTO:0002284
DR   EFO; EFO_0002829
DR   MCCL; MCC:0000326
DR   AddexBio; C0018008/403
DR   BCRJ; 0293
DR   ChEMBL-Cells; CHEMBL4483177
DR   ChEMBL-Targets; CHEMBL4483258
DR   IBRC; C10524
DR   Lonza; 163
DR   PRIDE; PXD000589
DR   PRIDE; PXD001081
DR   PubChem_Cell_line; CVCL_0431
DR   Wikidata; Q12513178
RX   PubMed=2163307;
RX   PubMed=8697299;
RX   PubMed=8824267;
RX   PubMed=18845907;
RX   PubMed=22538498;
RX   PubMed=22808281;
RX   PubMed=23560115;
RX   PubMed=25546123;
RX   PubMed=25894527;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-93.html
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Cell surface proteome.
CC   Omics: Endoplasmic reticulum proteome analysis.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: C57BL/6 IT6 transgenic.
DI   NCIt; C34053; Mouse insulinoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   13W
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 24
//
RX   PubMed=2163307; DOI=10.1210/endo-127-1-126;
RA   Miyazaki J.-i., Araki K., Yamato E., Ikegami H., Asano T.,
RA   Shibasaki Y., Oka Y., Yamamura K.-i.;
RT   "Establishment of a pancreatic beta cell line that retains
RT   glucose-inducible insulin secretion: special reference to expression
RT   of glucose transporter isoforms.";
RL   Endocrinology 127:126-132(1990).
//
RX   PubMed=8697299;
RA   Poitout V., Olson L.K., Robertson R.P.;
RT   "Insulin-secreting cell lines: classification, characteristics and
RT   potential applications.";
RL   Diabetes Metab. 22:7-14(1996).
//
RX   PubMed=8824267; DOI=10.1074/jbc.271.42.26194;
RA   Soejima A., Inoue K., Takai D., Kaneko M., Ishihara H., Oka Y.,
RA   Hayashi J.-i.;
RT   "Mitochondrial DNA is required for regulation of glucose-stimulated
RT   insulin secretion in a mouse pancreatic beta cell line, MIN6.";
RL   J. Biol. Chem. 271:26194-26199(1996).
//
RX   PubMed=18845907; DOI=10.1507/endocrj.K08E-172;
RA   Nakashima K., Kanda Y., Hirokawa Y., Kawasaki F., Matsuki M., Kaku K.;
RT   "MIN6 is not a pure beta cell line but a mixed cell line with other
RT   pancreatic endocrine hormones.";
RL   Endocr. J. 56:45-53(2009).
//
RX   PubMed=22538498; DOI=10.1159/000338793;
RA   Grozinsky-Glasberg S., Shimon I., Rubinfeld H.;
RT   "The role of cell lines in the study of neuroendocrine tumors.";
RL   Neuroendocrinology 96:173-187(2012).
//
RX   PubMed=22808281; DOI=10.1371/journal.pone.0040868;
RA   Cheng K., Delghingaro-Augusto V., Nolan C.J., Turner N., Hallahan N.,
RA   Andrikopoulos S., Gunton J.E.;
RT   "High passage MIN6 cells have impaired insulin secretion with impaired
RT   glucose and lipid oxidation.";
RL   PLoS ONE 7:E40868-E40868(2012).
//
RX   PubMed=23560115; DOI=10.1371/journal.pone.0061211;
RA   Yamato E., Tashiro F., Miyazaki J.-i.;
RT   "Microarray analysis of novel candidate genes responsible for
RT   glucose-stimulated insulin secretion in mouse pancreatic beta cell
RT   line MIN6.";
RL   PLoS ONE 8:E61211-E61211(2013).
//
RX   PubMed=25546123; DOI=10.1002/pmic.201400345;
RA   Lee J.-S., Wu Y.-N., Schnepp P., Fang J.-Y., Zhang X.-B., Karnovsky A.,
RA   Woods J., Stemmer P.M., Liu M., Zhang K.-Z., Chen X.-Q.;
RT   "Proteomics analysis of rough endoplasmic reticulum in pancreatic beta
RT   cells.";
RL   Proteomics 15:1508-1511(2015).
//
RX   PubMed=25894527; DOI=10.1371/journal.pone.0121314;
RA   Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F.,
RA   Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R.,
RA   Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P.,
RA   Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.;
RT   "A mass spectrometric-derived cell surface protein atlas.";
RL   PLoS ONE 10:E0121314-E0121314(2015).
//