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Cellosaurus MIO-M1 (CVCL_0433)

Cell line name MIO-M1
Synonyms Moorfields/Institute of Ophthalmology-Muller 1
Accession CVCL_0433
Resource Identification Initiative To cite this cell line use: MIO-M1 (RRID:CVCL_0433)
Comments Omics: Deep proteome analysis.
Omics: Metabolome analysis.
Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
Cell type: Muller glia; CL=CL_0011107.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Spontaneously immortalized cell line
Web pages https://xip.uclb.com/product/MIO_M1_cells
Publications

PubMed=11867609
Limb G.A., Salt T.E., Munro P.M.G., Moss S.E., Khaw P.T.
In vitro characterization of a spontaneously immortalized human Muller cell line (MIO-M1).
Invest. Ophthalmol. Vis. Sci. 43:864-869(2002)

PubMed=17525239; DOI=10.1634/stemcells.2006-0724
Lawrence J.M., Singhal S., Bhatia B., Keegan D.J., Reh T.A., Luthert P.J., Khaw P.T., Limb G.A.
MIO-M1 cells and similar Muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics.
Stem Cells 25:2033-2043(2007)

PubMed=22065927
Hollborn M., Ulbricht E., Rillich K., Dukic-Stefanovic S., Wurm A., Wagner L., Reichenbach A., Wiedemann P., Limb G.A., Bringmann A., Kohen L.
The human Muller cell line MIO-M1 expresses opsins.
Mol. Vis. 17:2738-2750(2011)

PubMed=30176221; DOI=10.1016/j.exer.2018.08.016
Eastlake K., Heywood W.E., Banerjee P., Bliss E., Mills K., Khaw P.T., Charteris D., Limb G.A.
Comparative proteomic analysis of normal and gliotic PVR retina and contribution of Muller glia to this profile.
Exp. Eye Res. 177:197-207(2018)

PubMed=31254428; DOI=10.1111/ceo.13578
Churm R., Dunseath G.J., Prior S.L., Thomas R.L., Banerjee S., Owens D.R.
Development and characterization of an in vitro system of the human retina using cultured cell lines.
Clin. Exp. Ophthalmol. 47:1055-1062(2019)

PubMed=32152301; DOI=10.1038/s41467-020-15066-6
Singh C., Tran V., McCollum L., Bolok Y., Allan K., Yuan A., Hoppe G., Brunengraber H., Sears J.E.
Hyperoxia induces glutamine-fuelled anaplerosis in retinal Muller cells.
Nat. Commun. 11:1277.1-1277.11(2020)

Cross-references
Cell line databases/resources MCCL; MCC:0000328
Anatomy/cell type resources BTO; BTO:0003062
Encyclopedic resources Wikidata; Q54905749
Metabolomic databases MetaboLights; MTBLS1228
Proteomic databases PRIDE; PXD008485
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number12