ID   MIO-M1
AC   CVCL_0433
SY   Moorfields/Institute of Ophthalmology-Muller 1
DR   BTO; BTO:0003062
DR   MCCL; MCC:0000328
DR   MetaboLights; MTBLS1228
DR   PRIDE; PXD008485
DR   Wikidata; Q54905749
RX   PubMed=11867609;
RX   PubMed=17525239;
RX   PubMed=22065927;
RX   PubMed=30176221;
RX   PubMed=31254428;
RX   PubMed=32152301;
WW   https://xip.uclb.com/product/MIO_M1_cells
CC   Omics: Deep proteome analysis.
CC   Omics: Metabolome analysis.
CC   Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
CC   Cell type: Muller glia; CL=CL_0011107.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 12
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RX   PubMed=11867609;
RA   Limb G.A., Salt T.E., Munro P.M.G., Moss S.E., Khaw P.T.;
RT   "In vitro characterization of a spontaneously immortalized human
RT   Muller cell line (MIO-M1).";
RL   Invest. Ophthalmol. Vis. Sci. 43:864-869(2002).
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RX   PubMed=17525239; DOI=10.1634/stemcells.2006-0724;
RA   Lawrence J.M., Singhal S., Bhatia B., Keegan D.J., Reh T.A.,
RA   Luthert P.J., Khaw P.T., Limb G.A.;
RT   "MIO-M1 cells and similar Muller glial cell lines derived from adult
RT   human retina exhibit neural stem cell characteristics.";
RL   Stem Cells 25:2033-2043(2007).
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RX   PubMed=22065927;
RA   Hollborn M., Ulbricht E., Rillich K., Dukic-Stefanovic S., Wurm A.,
RA   Wagner L., Reichenbach A., Wiedemann P., Limb G.A., Bringmann A.,
RA   Kohen L.;
RT   "The human Muller cell line MIO-M1 expresses opsins.";
RL   Mol. Vis. 17:2738-2750(2011).
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RX   PubMed=30176221; DOI=10.1016/j.exer.2018.08.016;
RA   Eastlake K., Heywood W.E., Banerjee P., Bliss E., Mills K., Khaw P.T.,
RA   Charteris D., Limb G.A.;
RT   "Comparative proteomic analysis of normal and gliotic PVR retina and
RT   contribution of Muller glia to this profile.";
RL   Exp. Eye Res. 177:197-207(2018).
//
RX   PubMed=31254428; DOI=10.1111/ceo.13578;
RA   Churm R., Dunseath G.J., Prior S.L., Thomas R.L., Banerjee S.,
RA   Owens D.R.;
RT   "Development and characterization of an in vitro system of the human
RT   retina using cultured cell lines.";
RL   Clin. Exp. Ophthalmol. 47:1055-1062(2019).
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RX   PubMed=32152301; DOI=10.1038/s41467-020-15066-6;
RA   Singh C., Tran V., McCollum L., Bolok Y., Allan K., Yuan A., Hoppe G.,
RA   Brunengraber H., Sears J.E.;
RT   "Hyperoxia induces glutamine-fuelled anaplerosis in retinal Muller
RT   cells.";
RL   Nat. Commun. 11:1277.1-1277.11(2020).
//