Cellosaurus MNNG/HOS Cl #5 (CVCL_0439)

Cell line name MNNG/HOS Cl #5
Synonyms MNNG/HOS; MNNG-HOS; HOS-MNNG; MNNGHOS; MNNG-HOS (Cl#5); MNNG/HOS Clone F-5; MNNG; R-1059-D; TE85; TE-85; HOS-TE85; Hos TE-85; HOS TE 85; HOS TE85; HOS (TE85); HOS(TE85); HOS (TE85, Clone F5); MNNG-HOS (TE 85, clone F-5); HOS-Te85; TE 85.T; TE 85 ClF-5
Accession CVCL_0439
Secondary accession CVCL_3952
Resource Identification Initiative To cite this cell line use: MNNG/HOS Cl #5 (RRID:CVCL_0439)
Comments Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Selected for resistance to: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Omics: Protein expression by reverse-phase protein arrays.
Disease Osteosarcoma (NCIt: C9145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0312 (HOS)
Children: CVCL_2402 (C1I); CVCL_2441 (E111); CVCL_4347 (II b); CVCL_2546 (KHOS/NP); CVCL_AU05 (KRIB); CVCL_9U38 (MNNG/HOS/DXR1000)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; CLS; ECACC; KCLB

Markers:
AmelogeninX
CSF1PO12
D13S31712
D16S53910,13
D18S5114
D21S1131.2
D3S135815
D5S81813
D7S82011,12
D8S117914
FGA24
Penta D9,10
Penta E7,12
TH016
TPOX8,11
vWA18
Web pages http://www.rccc.cytspb.rssi.ru/ecellbank/human/hMNNG-HOS%28TE85,clonF-5%29.htm
http://tcpaportal.org/mclp/
Publications

PubMed=265298; DOI=10.1002/ijc.2910190411
Rhim J.S., Putman D.L., Arnstein P., Huebner R.J., McAllister R.M.
Characterization of human cells transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine.
Int. J. Cancer 19:505-510(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2823272; DOI=10.1073/pnas.84.21.7716
Masuda H., Miller C., Koeffler H.P., Battifora H., Cline M.J.
Rearrangement of the p53 gene in human osteogenic sarcomas.
Proc. Natl. Acad. Sci. U.S.A. 84:7716-7719(1987)

PubMed=7873286; DOI=10.1016/8756-3282(94)90305-0
Clover J., Gowen M.
Are MG-63 and HOS TE85 human osteosarcoma cell lines representative models of the osteoblastic phenotype?
Bone 15:585-591(1994)

PubMed=12645653; DOI=10.1016/S0165-4608(02)00685-4
Ozaki T., Neumann T., Wai D.H., Schaefer K.-L., van Valen F., Lindner N., Scheel C., Bocker W., Winkelmann W., Dockhorn-Dworniczak B., Horst J., Poremba C.
Chromosomal alterations in osteosarcoma cell lines revealed by comparative genomic hybridization and multicolor karyotyping.
Cancer Genet. Cytogenet. 140:145-152(2003)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Mohseny A.B., Machado I., Cai Y., Schaefer K.-L., Serra M., Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Lab. Invest. 91:1195-1205(2011)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-1547
ATCC; CRL-7734 - Discontinued
ATCC; CRL-7735 - Discontinued
CLS; 300289/p447_MNNG-HOS
CLS; 300449/p503_HOS_(TE85)
ECACC; 87070201
KCLB; 21543
Cell line databases/resources CLDB; cl1703
CLDB; cl1704
CLDB; cl1705
CLDB; cl3510
Ontologies BTO; BTO:0005416
CLO; CLO_0003796
CLO; CLO_0007813
CLO; CLO_0007814
EFO; EFO_0002866
MCCL; MCC:0000334
Chemistry resources ChEMBL-Cells; CHEMBL3307282
ChEMBL-Targets; CHEMBL614038
ChEMBL-Targets; CHEMBL614173
Gene expression databases GEO; GSM879219
Polymorphism and mutation databases Cosmic; 1044084
Cosmic; 1074402
Cosmic; 1529901
Cosmic; 2301584