Cellosaurus MeWo (CVCL_0445)

Cell line name MeWo
Synonyms MEWO; Mewo; Me Wo; Me-Wo; Mevo; SK-MEL-MeWo; BI-Mel; EST50
Accession CVCL_0445
Resource Identification Initiative To cite this cell line use: MeWo (RRID:CVCL_0445)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
From: Memorial Sloan-Kettering Cancer Center; New York; USA.
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Heterozygous for MAPK3 p.Pro246Ser (ATCC).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_AZ60 (MeWo CIS 0.01); CVCL_AZ74 (MeWo CIS 1); CVCL_AZ61 (MeWo ETO 0.1); CVCL_AZ62 (MeWo ETO 1); CVCL_AZ75 (MeWo FOTE 4); CVCL_AZ76 (MeWo FOTE 40); CVCL_Y663 (MeWo LNI 6I); CVCL_AZ63 (MeWo VIN 0.5); CVCL_AZ77 (MeWo VIN 5); CVCL_U937 (MeWo-LC1); CVCL_J260 (Mewo-Luc)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP; ESTDAB; JCRB; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12 (ATCC; CLS; Cosmic-CLP; JCRB; PubMed=25877200)
10,12 (ESTDAB)
D13S3178 (Cosmic-CLP; ESTDAB)
8,9 (ATCC; CLS; JCRB; PubMed=25877200)
D16S53910,12
D18S5114,17
D21S1130,32.2
D3S135817
D5S81812,13
D7S82010,12
D8S117913,15
FGA22
Penta D10
Penta E5 (CLS)
5,15 (PubMed=25877200)
TH017,9
TPOX8,10 (ATCC; CLS; Cosmic-CLP; JCRB; PubMed=25877200)
9,11 (ESTDAB)
vWA15
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-532.html
Publications

PubMed=978138; DOI=10.1084/jem.144.4.873
Shiku H., Takahashi T., Oettgen H.F., Old L.J.
Cell surface antigens of human malignant melanoma. II. Serological typing with immune adherence assays and definition of two new surface antigens.
J. Exp. Med. 144:873-881(1976)

PubMed=1067619; DOI=10.1073/pnas.73.9.3278
Carey T.E., Takahashi T., Resnick L.A., Oettgen H.F., Old L.J.
Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells.
Proc. Natl. Acad. Sci. U.S.A. 73:3278-3282(1976)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6933476; DOI=10.1073/pnas.77.7.4260
Houghton A.N., Taormina M.C., Ikeda H., Watanabe T., Oettgen H.F., Old L.J.
Serological survey of normal humans for natural antibody to cell surface antigens of melanoma.
Proc. Natl. Acad. Sci. U.S.A. 77:4260-4264(1980)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=7175440; DOI=10.1084/jem.156.6.1755
Houghton A.N., Eisinger M., Albino A.P., Cairncross J.G., Old L.J.
Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.
J. Exp. Med. 156:1755-1766(1982)

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2068080; DOI=10.1073/pnas.88.14.6028
Cornil I., Theodorescu D., Man S., Herlyn M., Jambrosic J.A., Kerbel R.S.
Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.
Proc. Natl. Acad. Sci. U.S.A. 88:6028-6032(1991)

PubMed=1383272; DOI=10.1172/JCI116007
Nip J., Shibata H., Loskutoff D.J., Cheresh D.A., Brodt P.
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.
J. Clin. Invest. 90:1406-1413(1992)

PubMed=7908310; DOI=10.1080/09553009414550371
Muller W.-U., Bauch T., Streffer C., Niedereichholz F., Bocker W.
Comet assay studies of radiation-induced DNA damage and repair in various tumour cell lines.
Int. J. Radiat. Biol. 65:315-319(1994)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; HTB-65
BCRC; 60540
BCRJ; 0358
CLS; 300285/p1765_MEWO
ECACC; 93082609
ICLC; HTL97019
JCRB; JCRB0066
Cell line databases/resources CLDB; cl3456
CLDB; cl3458
CCLE; MEWO_SKIN
Cosmic-CLP; 908128
ESTDAB; ESTDAB-050
GDSC; 908128
LINCS_LDP; LCL-1253
Lonza; 437
Ontologies BTO; BTO:0003301
CLO; CLO_0007687
CLO; CLO_0007688
EFO; EFO_0006648
MCCL; MCC:0000341
Biological sample resources BioSample; SAMN01821578
BioSample; SAMN01821699
BioSample; SAMN03470821
Chemistry resources ChEMBL-Cells; CHEMBL3308024
ChEMBL-Targets; CHEMBL613300
Gene expression databases GEO; GSM156016
GEO; GSM188224
GEO; GSM188254
GEO; GSM188313
GEO; GSM206525
GEO; GSM274688
GEO; GSM827470
GEO; GSM887310
GEO; GSM888386
GEO; GSM1670097
Polymorphism and mutation databases Cosmic; 721835
Cosmic; 886829
Cosmic; 908128
Cosmic; 928689
Cosmic; 932713
Cosmic; 933141
Cosmic; 972284
Cosmic; 1047647
Cosmic; 1060422
Cosmic; 1132584
Cosmic; 1238113
Cosmic; 1303046
Cosmic; 1995506
Cosmic; 2036702
Cosmic; 2159442
Cosmic; 2163794