ID   NCI-H292
AC   CVCL_0455
SY   H292; H-292; NCI-HUT-292; Hut292; NCIH292
DR   BTO; BTO:0002418
DR   CLO; CLO_0008080
DR   EFO; EFO_0006690
DR   MCCL; MCC:0000353
DR   CLDB; cl3653
DR   CLDB; cl3654
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1848
DR   BCRC; 60372
DR   BCRJ; 0187
DR   BioSample; SAMN03471312
DR   BioSample; SAMN10988040
DR   CCLE; NCIH292_LUNG
DR   CCRID; 3111C0001CCC000233
DR   CCRID; 3131C0001000700122
DR   CCTCC; GDC0211
DR   Cell_Model_Passport; SIDM00493
DR   ChEMBL-Cells; CHEMBL3308637
DR   ChEMBL-Targets; CHEMBL614733
DR   Cosmic; 753604
DR   Cosmic; 844598
DR   Cosmic; 877404
DR   Cosmic; 1017828
DR   Cosmic; 1047099
DR   Cosmic; 1152499
DR   Cosmic; 1188584
DR   Cosmic; 1288262
DR   Cosmic; 1466803
DR   Cosmic; 1519249
DR   Cosmic; 1520933
DR   Cosmic; 1520947
DR   Cosmic; 1870272
DR   Cosmic; 1995573
DR   Cosmic; 2058648
DR   Cosmic; 2630420
DR   Cosmic; 2668261
DR   Cosmic-CLP; 753604
DR   DepMap; ACH-000474
DR   DepMap; ACH-001075
DR   ECACC; 91091815
DR   GDSC; 753604
DR   GEO; GSM206489
DR   GEO; GSM274745
DR   GEO; GSM274746
DR   GEO; GSM784237
DR   GEO; GSM794281
DR   GEO; GSM888505
DR   GEO; GSM1670237
DR   GEO; GSM2231213
DR   ICLC; HTL96009
DR   IARC_TP53; 21568
DR   KCB; KCB 200822YJ
DR   KCLB; 21848
DR   LiGeA; CCLE_170
DR   Lonza; 1440
DR   PharmacoDB; NCIH292_1103_2019
DR   PRIDE; PXD003086
DR   SKY/M-FISH/CGH; 2844
DR   Wikidata; Q54908015
RX   PubMed=1311061;
RX   PubMed=8806092;
RX   PubMed=12539049;
RX   PubMed=15193437;
RX   PubMed=17332333;
RX   PubMed=20164919;
RX   PubMed=22460905;
RX   PubMed=25485619;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   http://tcpaportal.org/mclp/
WW   http://www.cellresource.cn/fdetail.aspx?id=233
WW   http://www.cellresource.cn/fdetail.aspx?id=690
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Microsatellite instability: Instable (MSI-low) (Sanger).
CC   Sequence variation: CRTC1-MAML2 (MECT1-MAML2) gene fusion (PubMed=12539049; PubMed=25485619).
CC   Sequence variation: Heterozygous for NF2 p.Pro496fs*8 (c.1484_1485insA) (Cosmic-CLP).
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=81.43%; Native American=0.17%; East Asian, North=2.03%; East Asian, South=0%; South Asian=0.28%; European, North=6.04%; European, South=10.06% (PubMed=30894373).
CC   Discontinued: DepMap; ACH-000474; true.
CC   Discontinued: KCLB; 21848; probable.
ST   Source(s): ATCC; CCRID; Cosmic-CLP; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11,12
ST   D16S539: 9,13
ST   D18S51: 16
ST   D19S433: 12,13.2
ST   D21S11: 28
ST   D2S1338: 21,24
ST   D3S1358: 16
ST   D5S818: 13
ST   D7S820: 10
ST   D8S1179: 11,14
ST   FGA: 22,26
ST   Penta D: 9
ST   Penta E: 13,15
ST   TH01: 8
ST   TPOX: 8,11
ST   vWA: 16,17 (ATCC; Cosmic-CLP; PubMed=25877200)
ST   vWA: 16 (CCRID)
DI   NCIt; C45544; Lung mucoepidermoid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   32Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 06-09-19; Version: 27
//
RX   PubMed=1311061;
RA   Mitsudomi T., Steinberg S.M., Nau M.M., Carbone D., D'Amico D.,
RA   Bodner S., Oie H.K., Linnoila R.I., Mulshine J.L., Minna J.D.,
RA   Gazdar A.F.;
RT   "p53 gene mutations in non-small-cell lung cancer cell lines and their
RT   correlation with the presence of ras mutations and clinical
RT   features.";
RL   Oncogene 7:171-180(1992).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=12539049; DOI=10.1038/ng1083;
RA   Tonon G., Modi S., Wu L., Kubo A., Coxon A.B., Komiya T., O'Neil K.,
RA   Stover K., El-Naggar A., Griffin J.D., Kirsch I.R., Kaye F.J.;
RT   "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a
RT   novel fusion product that disrupts a Notch signaling pathway.";
RL   Nat. Genet. 33:208-213(2003).
//
RX   PubMed=15193437; DOI=10.1016/j.cancergencyto.2003.10.007;
RA   Tonon G., Gehlhaus K.S., Yonescu R., Kaye F.J., Kirsch I.R.;
RT   "Multiple reciprocal translocations in salivary gland mucoepidermoid
RT   carcinomas.";
RL   Cancer Genet. Cytogenet. 152:15-22(2004).
//
RX   PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339;
RA   Okabe T., Okamoto I., Tamura K., Terashima M., Yoshida T., Satoh T.,
RA   Takada M., Fukuoka M., Nakagawa K.;
RT   "Differential constitutive activation of the epidermal growth factor
RT   receptor in non-small cell lung cancer cells bearing EGFR gene
RT   mutation and amplification.";
RL   Cancer Res. 67:2046-2053(2007).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P.,
RA   Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//