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Cellosaurus NCI-H295R (CVCL_0458)

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Cell line name NCI-H295R
Synonyms NCI H295R; NCIH295R; H295R; H-295R; H295R-S1
Accession CVCL_0458
Resource Identification Initiative To cite this cell line use: NCI-H295R (RRID:CVCL_0458)
Comments Characteristics: Grows in a medium called Nu-Serum type I.
Doubling time: 25 hours (PubMed=29371329).
Omics: SNP array analysis.
Derived from sampling site: Adrenal gland.
Sequence variations Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (from parent cell line).
Disease Adrenal cortex carcinoma (NCIt: C9325)
Adrenocortical carcinoma (ORDO: Orphanet_1501)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0456 (NCI-H295)
CVCL_5V09 (HAC13)CVCL_S898 (HAC15)CVCL_5V08 (HAC50)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; CLS

Penta D8
Penta E5,12

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/H295R

PubMed=15541570; DOI=10.1016/j.mce.2003.12.020
Rainey W.E., Saner K., Schimmer B.P.
Adrenocortical cell lines.
Mol. Cell. Endocrinol. 228:23-38(2004)

PubMed=18000308; DOI=10.1677/JOE-07-0166
Samandari E., Kempna P., Nuoffer J.M., Hofer G., Mullis P.E., Fluck C.E.
Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities.
J. Endocrinol. 195:459-472(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21924324; DOI=10.1016/j.mce.2011.08.041
Wang T., Rainey W.E.
Human adrenocortical carcinoma cell lines.
Mol. Cell. Endocrinol. 351:58-65(2012)

PubMed=22266826; DOI=10.1055/s-0031-1298019
Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.
Comparison of aldosterone production among human adrenocortical cell lines.
Horm. Metab. Res. 44:245-250(2012)

PubMed=23951072; DOI=10.1371/journal.pone.0071022
Nishi H., Arai H., Momiyama T.
NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca(2)(+)-mobilization/influx and cortisol secretion.
PLoS ONE 8:E71022-E71022(2013)

PubMed=29371329; DOI=10.1530/ERC-17-0447
Kiseljak-Vassiliades K., Zhang Y., Bagby S.M., Kar A., Pozdeyev N., Xu M., Gowan K., Sharma V., Raeburn C.D., Albuja-Cruz M.B., Jones K.L., Fishbein L., Schweppe R.E., Somerset H.L., Pitts T.M., Leong S., Wierman M.E.
Development of new preclinical models to advance adrenocortical carcinoma research.
Endocr. Relat. Cancer 25:437-451(2018)

Cell line collections ATCC; CRL-2128
CLS; 300483/p789_NCI-H295R
KCB; KCB 201509YJ
Cell line databases/resources CCRID; 3111C0001CCC000256
Lonza; 378
Ontologies BTO; BTO:0002588
CLO; CLO_0008082
EFO; EFO_0002289
MCCL; MCC:0000355
Chemistry resources ChEMBL-Cells; CHEMBL3307998
ChEMBL-Targets; CHEMBL612593
Gene expression databases ArrayExpress; E-MTAB-38
Other Wikidata; Q25323725
Polymorphism and mutation databases Cosmic; 1172633
Cosmic; 1191070
Cosmic; 1622873
Cosmic; 2364101
Cosmic; 2574494
Progenetix; CVCL_0458
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number20