Cell line name | NCI-H157 | ||||||||||||||||||||||||||||||||
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Synonyms | NCl-H157; NCI H157; H157; H-157; NCI-157 | ||||||||||||||||||||||||||||||||
Accession | CVCL_0463 | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: NCI-H157 (RRID:CVCL_0463) | ||||||||||||||||||||||||||||||||
Comments | Problematic cell line: Contaminated. NCI-H157 and NCI-H1264 have been shown to be identical. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00412. Doubling time: 53 hours (in RPMI 1640 + 10% FBS), 90 hours (in ACL-3 + BSA) (PubMed=3940644); 20.8 hours (PubMed=29681454). Omics: Deep exome analysis. Omics: Deep proteome analysis. Omics: miRNA expression profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis. | ||||||||||||||||||||||||||||||||
Sequence variations | CDKN2A p.His83Tyr (c.247C>T) (p.Ala97Val; c.290C>T) (ClinVar=VCV000376307) (PubMed=30038707).KRAS p.Gly12Arg (c.34G>C) (ClinVar=VCV000012579) (PubMed=1311061; PubMed=12068308).TP53 p.Glu298Ter (c.892G>T) (ClinVar=VCV000093323) (PubMed=1311061). | ||||||||||||||||||||||||||||||||
Disease | Lung squamous cell carcinoma (NCIt: C3493) | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Originate from same individual | CVCL_3970 ! NCI-H1264 | ||||||||||||||||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||||||||||||||||
Age at sampling | 59Y | ||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): ATCC; CCRID Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Web pages | http://www.cellresource.cn/fdetail.aspx?id=113 https://www.atcc.org/support/faqs/05d55/Cross-contamination%20of%20ATCC%20CRL-5802%20and%20ATCC%20CRL-5860-931.aspx https://www.atcc.org/support/faqs/78ebc/Contaminating%20Line%20for%20ATCC%20CRL5802%20vs%20ATCC%20CRL5860-932.aspx https://www.atcc.org/support/faqs/bb641/Misidentified%20Cell%20Lines%20ATCC%20CRL-5802%20and%20ATCC%20CRL-5860-930.aspx http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx | ||||||||||||||||||||||||||||||||
Publications | PubMed=6148444; DOI=10.1093/jnci/73.4.801 PubMed=3940644 PubMed=1311061 PubMed=1563005 PubMed=7972006; DOI=10.1073/pnas.91.23.11045 PubMed=8626706; DOI=10.1074/jbc.271.19.11477 PubMed=8806092; DOI=10.1002/jcb.240630505 PubMed=9649128; DOI=10.1038/bjc.1998.361 PubMed=11005564; DOI=10.1038/sj.neo.7900094 PubMed=11369051; DOI=10.1016/S0165-4608(00)00363-0 PubMed=12068308; DOI=10.1038/nature00766 PubMed=19472407; DOI=10.1002/humu.21028 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=20624269; DOI=10.1186/1756-9966-29-75 PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112 PubMed=23381221; DOI=10.3892/or.2013.2266 PubMed=25120651; DOI=10.3892/ol.2014.2234 PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003 PubMed=29681454; DOI=10.1016/j.cell.2018.03.028 PubMed=30038707; DOI=10.18632/oncotarget.25642 PubMed=31803961; DOI=10.1002/jcb.29564 | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Cell line collections | ATCC; CRL-5802 - Discontinued
KCB; KCB 200814YJ KCLB; 90157 - Discontinued | ||||||||||||||||||||||||||||||||
Cell line databases/resources | CCRID; 3111C0001CCC000113
IGRhCellID; H157GEO LINCS_LDP; LCL-1596 | ||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0002283
EFO; EFO_0003118 MCCL; MCC:0000360 | ||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03151855
BioSample; SAMN03471738 | ||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307706
ChEMBL-Targets; CHEMBL614783 | ||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-783
GEO; GSM6296 GEO; GSM253365 GEO; GSM434267 GEO; GSM784238 GEO; GSM794274 | ||||||||||||||||||||||||||||||||
Other | Wikidata; Q54907822 | ||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 722053
Cosmic; 724867 Cosmic; 801588 Cosmic; 844816 Cosmic; 852006 Cosmic; 876171 Cosmic; 877258 Cosmic; 903569 Cosmic; 911847 Cosmic; 917987 Cosmic; 929971 Cosmic; 930486 Cosmic; 932921 Cosmic; 934546 Cosmic; 953987 Cosmic; 949208 Cosmic; 980960 Cosmic; 1028954 Cosmic; 1032432 Cosmic; 1146881 Cosmic; 1219061 Cosmic; 1239910 Cosmic; 1320185 Cosmic; 2560227 Cosmic; 2648437 Cosmic; 2668267 Cosmic; 2668329 IARC_TP53; 495 IARC_TP53; 28242 Progenetix; CVCL_0463 | ||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD002556 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||
Last entry update | 29-Oct-2020 | ||||||||||||||||||||||||||||||||
Version number | 30 |