ID   NRK-52E
AC   CVCL_0468
SY   NRK 52E; NRK52E; NRK clone 52E; Normal Rat Kidney-52E; NRK-E52
DR   BTO; BTO:0002408
DR   CLO; CLO_0008198
DR   MCCL; MCC:0000366
DR   CLDB; cl3732
DR   CLDB; cl3733
DR   ATCC; CRL-1571
DR   BCRC; 60086
DR   CCRID; 1101RAT-PUMC000822
DR   CCRID; 3101RATGNR8
DR   ChEMBL-Cells; CHEMBL4483159
DR   ChEMBL-Targets; CHEMBL4483282
DR   CLS; 305196
DR   DSMZ; ACC-199
DR   DSMZCellDive; ACC-199
DR   ECACC; 87012902
DR   GEO; GSM4009053
DR   GEO; GSM4009054
DR   GEO; GSM4009055
DR   JCRB; IFO50480
DR   Lonza; 147
DR   PRIDE; PXD021160
DR   PubChem_Cell_line; CVCL_0468
DR   TOKU-E; 2774
DR   Wikidata; Q54931030
RX   PubMed=304450;
RX   PubMed=7732277;
RX   PubMed=29460274;
RX   PubMed=33122286;
WW   https://www.atcc.org/en/support/technical-support/faqs/lifespan-of-the-cell-line-nrk-52e-atcc-crl-1571
CC   Doubling time: ~45 hours (DSMZ=ACC-199).
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Breed/subspecies: Osborne-Mendel.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_3758 ! NRK
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 23
//
RX   PubMed=304450; DOI=10.1002/jcp.1040940311;
RA   De Larco J.E., Todaro G.J.;
RT   "Epithelioid and fibroblastic rat kidney cell clones: epidermal growth
RT   factor (EGF) receptors and the effect of mouse sarcoma virus
RT   transformation.";
RL   J. Cell. Physiol. 94:335-342(1978).
//
RX   PubMed=7732277; DOI=10.1177/019262339402200604;
RA   Davis M.A., Smith M.W., Chang S.H., Trump B.F.;
RT   "Characterization of a renal epithelial cell model of apoptosis using
RT   okadaic acid and the NRK-52E cell line.";
RL   Toxicol. Pathol. 22:595-605(1994).
//
RX   PubMed=29460274; DOI=10.1002/bit.26574;
RA   Yeste J., Martinez-Gimeno L., Illa X., Laborda P., Guimera A.,
RA   Sanchez-Marin J.P., Villa R., Gimenez I.;
RT   "A perfusion chamber for monitoring transepithelial NaCl transport in
RT   an in vitro model of the renal tubule.";
RL   Biotechnol. Bioeng. 115:1604-1613(2018).
//
RX   PubMed=33122286; DOI=10.1681/ASN.2020010009;
RA   Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.;
RT   "Transcriptomes of major proximal tubule cell culture models.";
RL   J. Am. Soc. Nephrol. 32:86-97(2021).
//