Cellosaurus OE33 (CVCL_0471)

Cell line name OE33
Synonyms OE-33; JROECL 33; JROECL33; OEC33
Accession CVCL_0471
Resource Identification Initiative To cite this cell line use: OE33 (RRID:CVCL_0471)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Doubling time: 33 hours (PubMed=25984343); ~30 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: TP53 p.Cys135Tyr (PubMed=20075370).
Omics: Chromatin accessibility by ATAC-seq.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Barrett adenocarcinoma (NCIt: C7027)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; ECACC; PubMed=20075370; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11 (Cosmic-CLP; DSMZ; PubMed=20075370)
10 (ECACC; PubMed=25877200)
D13S31714
D16S53912
D18S5112
D19S43312,15,16
D21S1129,31.2
D2S133817,19,20
D3S135818
D5S81811
D7S8209,10
D8S117910,11,12 (PubMed=20075370)
10,12 (PubMed=25877200)
FGA23
Penta D9,11
Penta E12,18
TH017,8 (Cosmic-CLP; ECACC; PubMed=20075370; PubMed=25877200)
7 (DSMZ)
TPOX8,11
vWA17 (Cosmic-CLP; DSMZ; ECACC; PubMed=20075370)
14,17 (PubMed=25877200)
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=9010035; DOI=10.1038/bjc.1997.42
Rockett J.C., Larkin K., Darnton S.J., Morris A.G., Matthews H.R.
Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization.
Br. J. Cancer 75:258-263(1997)

PubMed=11520067; DOI=10.1006/bbrc.2001.5400
Kan T., Shimada Y., Sato F., Maeda M., Kawabe A., Kaganoi J.-I., Itami A., Yamasaki S., Imamura M.
Gene expression profiling in human esophageal cancers using cDNA microarray.
Biochem. Biophys. Res. Commun. 286:792-801(2001)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

DOI=10.12688/f1000research.7033.1
Contino G., Eldridge M.D., Secrier M., Bower L., Elliott R.F., Weaver J., Lynch A.G., Edwards P.A.W., Fitzgerald R.C.
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336-1336(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27600491; DOI=10.1038/srep32417
Garcia E., Hayden A., Birts C., Britton E., Cowie A., Pickard K., Mellone M., Choh C., Derouet M., Duriez P., Noble F., White M.J., Primrose J.N., Strefford J.C., Rose-Zerilli M., Thomas G.J., Ang Y., Sharrocks A.D., Fitzgerald R.C., Underwood T.J.
Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.
Sci. Rep. 6:32417-32417(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28504813; DOI=10.3892/or.2017.5640
Melsens E., De Vlieghere E., Descamps B., Vanhove C., De Wever O., Ceelen W., Pattyn P.
Improved xenograft efficiency of esophageal adenocarcinoma cell lines through in vivo selection.
Oncol. Rep. 38:71-81(2017)

Cross-references
Cell line collections AddexBio; C0013003/115
AddexBio; C0013004/121
DSMZ; ACC-706
ECACC; 96070808
Cell line databases/resources CLDB; cl3762
CCLE; OE33_OESOPHAGUS
Cosmic-CLP; 910549
GDSC; 910549
IGRhCellID; OE33
LINCS_LDP; LCL-1797
Ontologies BTO; BTO:0003541
CLO; CLO_0008240
EFO; EFO_0002310
MCCL; MCC:0000369
Biological sample resources BioSample; SAMN03472890
BioSample; SAMN03473392
Chemistry resources ChEMBL-Cells; CHEMBL3308776
ChEMBL-Targets; CHEMBL1075556
Gene expression databases GEO; GSM827306
GEO; GSM887476
GEO; GSM888557
GEO; GSM1375731
GEO; GSM1375732
GEO; GSM1375733
GEO; GSM1375734
GEO; GSM1375743
GEO; GSM1375744
GEO; GSM1375745
GEO; GSM1375746
GEO; GSM1375755
GEO; GSM1375756
GEO; GSM1375757
GEO; GSM1375758
GEO; GSM1670304
Polymorphism and mutation databases Cosmic; 871233
Cosmic; 910549
Cosmic; 978855
Cosmic; 997861
Cosmic; 1175877
Cosmic; 1599343
Cosmic; 1618820