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Cellosaurus PC12 (CVCL_0481)

Cell line name PC12
Synonyms PC-12; PC 12
Accession CVCL_0481
Resource Identification Initiative To cite this cell line use: PC12 (RRID:CVCL_0481)
Comments Characteristics: Responds reversibly to NGF by induction of a neuronal phenotype.
Doubling time: ~50-60 hours (DSMZ); 92 hours (CLS; ECACC).
Disease Rat adrenal gland pheochromocytoma (NCIt: C121568)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH.
Hierarchy Children:
CVCL_0109 (123.7)CVCL_0133 (A126-1B2)CVCL_X983 (A208-4)
CVCL_X984 (A208-7)CVCL_X985 (AB.11)CVCL_JY59 (Neuroscreen-1)
CVCL_F659 (PC-12 Adh)CVCL_AU97 (PC-12 HD-Q23 cell 14)CVCL_AU98 (PC-12 HD-Q23 cell 7)
CVCL_AU99 (PC-12 HD-Q74 cell 10)CVCL_AV00 (PC-12 HD-Q74 cell 1b)CVCL_5574 (PC-12TG)
CVCL_DN60 (PC12 HTT-SW2-Q145 clone 14)CVCL_DN61 (PC12 HTT-SW2-Q145-TagRFP clone 5)CVCL_DN62 (PC12 HTT-SW2-Q23 clone 28)
CVCL_DN63 (PC12 HTT-SW2-Q23-TagRFP clone 34)CVCL_DN64 (PC12 HTT-SW2-Q73 clone 29)CVCL_DN65 (PC12 HTT-SW2-Q73-TagRFP clone 17)
CVCL_V361 (PC12 Tet-Off)CVCL_V333 (PC12 Tet-On)CVCL_VH13 (PC12-1G2)
CVCL_VH10 (PC12-2B3)CVCL_C130 (PC12-615)CVCL_J442 (PC12-AC)
CVCL_VH11 (PC12-C3)CVCL_VH12 (PC12-D60)CVCL_T752 (PC12-F7)
CVCL_T753 (PC12-G11)CVCL_5573 (PC12.P3)CVCL_4681 (PC12D)
CVCL_JX88 (PC12h)CVCL_J438 (PC12HS)CVCL_J440 (PC12IS)
CVCL_4925 (PC12K)CVCL_J441 (PC12MS)CVCL_C126 (PC12nnr14)
CVCL_C127 (PC12nnr3)CVCL_C128 (PC12nnr5)CVCL_C129 (PC12nnr6)
CVCL_0483 (PC2)CVCL_7090 (PC4)CVCL_7091 (PC6)
Sex of cell Male
Category Cancer cell line
Web pages https://en.wikipedia.org/wiki/PC12_cell
https://www.atcc.org/support/faqs/2ef3f/PC12%20Cells%20%20ATCC%20CRL1721%20vs%20ATCC%20CRL17211-783.aspx
http://www.cells-talk.com/index.php/page/copelibrary?key=PC12
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/p/cell-lines-detail-11.html
http://php.med.unsw.edu.au/cellbiology/index.php?title=Cells_-_PC12
Publications

PubMed=1065897; DOI=10.1073/pnas.73.7.2424
Greene L.A., Tischler A.S.
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
Proc. Natl. Acad. Sci. U.S.A. 73:2424-2428(1976)

PubMed=682602
Tischler A.S., Greene L.A.
Morphologic and cytochemical properties of a clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
Lab. Invest. 39:77-89(1978)

PubMed=2493070; DOI=10.1111/j.1471-4159.1989.tb02538.x
Katoh-Semba R., Oohira A., Sano M., Watanabe K., Kitajima S., Kashiwamata S.
Glycosaminoglycan composition of PC12 pheochromocytoma cells: a comparison with PC12D cells, a new subline of PC12 cells.
J. Neurochem. 52:889-895(1989)

PubMed=15541571; DOI=10.1016/j.mce.2003.02.001
Eaton M.J., Duplan H.
Useful cell lines derived from the adrenal medulla.
Mol. Cell. Endocrinol. 228:39-52(2004)

PubMed=16223334; DOI=10.1290/0411077.1
Dixon D.N., Loxley R.A., Barron A., Cleary S., Phillips J.K.
Comparative studies of PC12 and mouse pheochromocytoma-derived rodent cell lines as models for the study of neuroendocrine systems.
In Vitro Cell. Dev. Biol. Anim. 41:197-206(2005)

PubMed=18005394; DOI=10.1111/j.1748-1716.2007.01805.x
Westerink R.H.S., Ewing A.G.
The PC12 cell as model for neurosecretion.
Acta Physiol. 192:273-285(2008)

PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

Cross-references
Cell line collections AddexBio; C0032001/4927
ATCC; CRL-1721
BCRC; 60048
BCRJ; 0203
CLS; 500311/p701_PC-12
DSMZ; ACC-159
ECACC; 88022401
ICLC; ATL98004
IZSLER; BS TCL 91
JCRB; IFO50278
JCRB; JCRB0733
KCB; KCB 93033YJ
KCB; KCB 200735YJ
KCB; KCB 200736YJ
KCLB; 21721
NCBI_Iran; C153
RCB; RCB0009
Cell line databases/resources CLDB; cl3876
CLDB; cl3877
CLDB; cl3878
CLDB; cl4922
CLDB; cl5245
CCRID; 3111C0001CCC000024
CCRID; 3131C0001001000003
CCRID; 3142C0001000000006
CCRID; 3153C0001000000030
Lonza; 124
TOKU-E; 2867
TOKU-E; 3554
Ontologies BTO; BTO:0001009
CLO; CLO_0008392
CLO; CLO_0050821
EFO; EFO_0001225
MCCL; MCC:0000379
MeSH; D016716
Chemistry resources ChEMBL-Cells; CHEMBL3307976
ChEMBL-Targets; CHEMBL612556
Other Wikidata; Q7118481