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Cellosaurus PC12 (CVCL_0481)

[Text version]

Cell line name PC12
Synonyms PC-12; PC 12
Accession CVCL_0481
Resource Identification Initiative To cite this cell line use: PC12 (RRID:CVCL_0481)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Responds reversibly to NGF by induction of a neuronal phenotype.
Doubling time: ~50-60 hours (DSMZ); 92 hours (CLS; ECACC).
Derived from sampling site: Adrenal gland.
Disease Rat adrenal gland pheochromocytoma (NCIt: C121568)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH.
Hierarchy Children:
CVCL_0109 (123.7)CVCL_0133 (A126-1B2)CVCL_X983 (A208-4)
CVCL_X984 (A208-7)CVCL_X985 (AB.11)CVCL_YJ89 (LINTERNA PC-12)
CVCL_JY59 (Neuroscreen-1)CVCL_F659 (PC-12 Adh)CVCL_AU97 (PC-12 HD-Q23 cell 14)
CVCL_AU98 (PC-12 HD-Q23 cell 7)CVCL_AU99 (PC-12 HD-Q74 cell 10)CVCL_AV00 (PC-12 HD-Q74 cell 1b)
CVCL_5574 (PC-12TG)CVCL_DN60 (PC12 HTT-SW2-Q145 clone 14)CVCL_DN61 (PC12 HTT-SW2-Q145-TagRFP clone 5)
CVCL_DN62 (PC12 HTT-SW2-Q23 clone 28)CVCL_DN63 (PC12 HTT-SW2-Q23-TagRFP clone 34)CVCL_DN64 (PC12 HTT-SW2-Q73 clone 29)
CVCL_DN65 (PC12 HTT-SW2-Q73-TagRFP clone 17)CVCL_V361 (PC12 Tet-Off)CVCL_V333 (PC12 Tet-On)
CVCL_VH13 (PC12-1G2)CVCL_VH10 (PC12-2B3)CVCL_C130 (PC12-615)
CVCL_J442 (PC12-AC)CVCL_VH11 (PC12-C3)CVCL_VH12 (PC12-D60)
CVCL_T752 (PC12-F7)CVCL_T753 (PC12-G11)CVCL_5573 (PC12.P3)
CVCL_4681 (PC12D)CVCL_JX88 (PC12h)CVCL_J438 (PC12HS)
CVCL_J440 (PC12IS)CVCL_4925 (PC12K)CVCL_J441 (PC12MS)
CVCL_C126 (PC12nnr14)CVCL_C127 (PC12nnr3)CVCL_C128 (PC12nnr5)
CVCL_C129 (PC12nnr6)CVCL_0483 (PC2)CVCL_7090 (PC4)
CVCL_7091 (PC6)
Sex of cell Male
Category Cancer cell line
Web pages https://en.wikipedia.org/wiki/PC12_cell

PubMed=1065897; DOI=10.1073/pnas.73.7.2424
Greene L.A., Tischler A.S.
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
Proc. Natl. Acad. Sci. U.S.A. 73:2424-2428(1976)

Tischler A.S., Greene L.A.
Morphologic and cytochemical properties of a clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
Lab. Invest. 39:77-89(1978)

PubMed=6500171; DOI=10.1016/0303-7207(84)90102-3
Bethea C.L., Kozak S.L.
Effect of extracellular matrix on PC 12 cell shape and dopamine processing.
Mol. Cell. Endocrinol. 37:319-329(1984)

PubMed=2493070; DOI=10.1111/j.1471-4159.1989.tb02538.x
Katoh-Semba R., Oohira A., Sano M., Watanabe K., Kitajima S., Kashiwamata S.
Glycosaminoglycan composition of PC12 pheochromocytoma cells: a comparison with PC12D cells, a new subline of PC12 cells.
J. Neurochem. 52:889-895(1989)

PubMed=2759161; DOI=10.1016/0277-5379(89)90388-X
Chelmicka-Schorr E., Checinski M.E., Arnason B.G.W.
PC12 pheochromocytoma and sympathetic nervous system derived trophic factors augment growth of neuroblastoma.
Eur. J. Cancer Clin. Oncol. 25:1057-1059(1989)

PubMed=2187480; DOI=10.1089/dna.1990.9.221
Muller S.R., Sullivan P.D., Clegg D.O., Feinstein S.C.
Efficient transfection and expression of heterologous genes in PC12 cells.
DNA Cell Biol. 9:221-229(1990)

PubMed=15541571; DOI=10.1016/j.mce.2003.02.001
Eaton M.J., Duplan H.
Useful cell lines derived from the adrenal medulla.
Mol. Cell. Endocrinol. 228:39-52(2004)

PubMed=16223334; DOI=10.1290/0411077.1
Dixon D.N., Loxley R.A., Barron A., Cleary S., Phillips J.K.
Comparative studies of PC12 and mouse pheochromocytoma-derived rodent cell lines as models for the study of neuroendocrine systems.
In Vitro Cell. Dev. Biol. Anim. 41:197-206(2005)

PubMed=18005394; DOI=10.1111/j.1748-1716.2007.01805.x
Westerink R.H.S., Ewing A.G.
The PC12 cell as model for neurosecretion.
Acta Physiol. 192:273-285(2008)

PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

Cell line collections AddexBio; C0032001/4927
ATCC; CRL-1721
BCRC; 60048
BCRJ; 0203
CLS; 500311/p701_PC-12
ECACC; 88022401
ICLC; ATL98004
JCRB; IFO50278
KCB; KCB 93033YJ
KCB; KCB 200735YJ
KCB; KCB 200736YJ
KCLB; 21721
NCBI_Iran; C153
RCB; RCB0009
Cell line databases/resources CLDB; cl3876
CLDB; cl3877
CLDB; cl3878
CLDB; cl4922
CLDB; cl5245
CCRID; 3111C0001CCC000024
CCRID; 3131C0001001000003
CCRID; 3142C0001000000006
CCRID; 3153C0001000000030
Lonza; 124
TOKU-E; 2867
TOKU-E; 3554
Ontologies BTO; BTO:0001009
CLO; CLO_0008392
CLO; CLO_0050821
EFO; EFO_0001225
MCCL; MCC:0000379
MeSH; D016716
Chemistry resources ChEMBL-Cells; CHEMBL3307976
ChEMBL-Targets; CHEMBL612556
Other Wikidata; Q7118481
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number23