ID   RAW 264.7
AC   CVCL_0493
SY   RAW264; RAW2647; RAW264.7; RAW-264.7; Raw 264.7; Raw264.7
DR   BTO; BTO:0003292
DR   CLO; CLO_0008753
DR   CLO; CLO_0051424
DR   EFO; EFO_0001231
DR   MCCL; MCC:0000390
DR   CLDB; cl4110
DR   CLDB; cl7129
DR   Abcam; ab275474
DR   AddexBio; C0003008/444
DR   ATCC; TIB-71
DR   BCRC; 60001
DR   BCRJ; 0212
DR   BioSample; SAMN11397665
DR   CCRID; 1101MOU-PUMC000146
DR   CCRID; 3101MOUSCSP5036
DR   CCRID; 3101MOUTCM13
DR   CCRID; 4201MOU-CCTCC00143
DR   CCRID; 6101MOU-CERC000109
DR   CCTCC; GDC0143
DR   ChEMBL-Cells; CHEMBL3307977
DR   ChEMBL-Targets; CHEMBL612557
DR   CLS; 400319
DR   ECACC; 91062702
DR   FCS-free; 225-5-468-2-3-3
DR   IBRC; C10072
DR   ICLC; ATL02001
DR   IZSLER; BS TCL 177
DR   KCB; KCB 200603YJ
DR   KCLB; 40071
DR   Lonza; 674
DR   MeSH; D000067996
DR   MetaboLights; MTBLS23
DR   MetaboLights; MTBLS636
DR   MetaboLights; MTBLS696
DR   MetaboLights; MTBL1140
DR   NCBI_Iran; C639
DR   PRIDE; PXD000984
DR   PRIDE; PXD001293
DR   PRIDE; PXD001905
DR   PRIDE; PXD001935
DR   PRIDE; PXD003545
DR   PubChem_Cell_line; CVCL_0493
DR   TOKU-E; 2976
DR   TOKU-E; 4095
DR   Ubigene; YC-C020
DR   Wikidata; Q28335461
RX   DOI=10.5897/IJBMBR2013.0154;
RX   PubMed=212198;
RX   PubMed=3792703;
RX   PubMed=16948499;
RX   PubMed=19057837;
RX   PubMed=19144319;
RX   PubMed=22735334;
RX   PubMed=23430347;
RX   PubMed=25277546;
RX   PubMed=25504905;
RX   PubMed=29889899;
RX   PubMed=31220119;
RX   PubMed=31947698;
RX   PubMed=33389257;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=RAW264.7
WW   https://www.atcc.org/en/support/technical-support/faqs/morphology-of-atcc-tib-71
WW   https://www.atcc.org/en/support/technical-support/faqs/tib-71-growth-and-morphology
WW   https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/r/cell-lines-detail-325.html
CC   Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
CC   Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
CC   Doubling time: 11 hours (Note=From cell counting), 12 hours (Note=From absorbance) (DOI=10.5897/IJBMBR2013.0154); ~30 hours (CLS=400319).
CC   Transformant: NCBI_TaxID; 11788; Abelson mouse leukemia virus (AbMuLV).
CC   Omics: Metabolome analysis.
CC   Omics: Phagosome quantitative phosphoproteome analysis.
CC   Omics: Phagosome proteome analysis.
CC   Omics: SNP array analysis.
CC   Miscellaneous: PubMed=23430347 has a different value for STR 6-4 (17) than that of NIST (18) due to a change in the marker motif (personal communication of Almeida J.L.).
CC   Misspelling: RAW 267.4; Note=Occasionally.
CC   Misspelling: Raw 267.4; Note=Occasionally.
CC   Misspelling: RAW267.4; Note=Occasionally.
CC   Misspelling: RAW 274; Note=Occasionally.
CC   Misspelling: RAW-274; Note=Occasionally.
CC   Misspelling: RAW274; Note=Occasionally.
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Macrophage; CL=CL_0000235.
CC   Breed/subspecies: BALB/c.
ST   Source(s): PubMed=23430347; PubMed=31220119; Ubigene
ST   Mouse STR 1-1: 15,16
ST   Mouse STR 1-2: 17
ST   Mouse STR 11-2: 17
ST   Mouse STR 12-1: 16
ST   Mouse STR 13-1: 16.2
ST   Mouse STR 15-3: 22.3
ST   Mouse STR 17-2: 14,16
ST   Mouse STR 18-3: 18
ST   Mouse STR 19-2: 14
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 14
ST   Mouse STR 4-2: 22.3
ST   Mouse STR 5-5: 14
ST   Mouse STR 6-4: 18
ST   Mouse STR 6-7: 12
ST   Mouse STR 7-1: 25.2
ST   Mouse STR 8-1: 13
ST   Mouse STR 9-2: 15
ST   Mouse STR X-1: 24
DI   NCIt; C21604; Mouse leukemia
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_4478 ! RAW 264
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 37
//
RX   DOI=10.5897/IJBMBR2013.0154;
RA   Iloki Assanga S.B., Gil-Salido A.A., Lewis Lujan L.M., Rosas-Durazo A.,
RA   Acosta-Silva A.L., Rivera-Castaneda E.G., Rubio-Pino J.L.;
RT   "Cell growth curves for different cell lines and their relationship
RT   with biological activities.";
RL   Int. J. Biotechnol. Mol. Biol. Res. 4:60-70(2013).
//
RX   PubMed=212198; DOI=10.1016/0092-8674(78)90101-0;
RA   Raschke W.C., Baird S., Ralph P., Nakoinz I.;
RT   "Functional macrophage cell lines transformed by Abelson leukemia
RT   virus.";
RL   Cell 15:261-267(1978).
//
RX   PubMed=3792703; DOI=10.1111/j.1432-0436.1986.tb00568.x;
RA   Leenen P.J.M., Jansen A.M.A.C., van Ewijk W.;
RT   "Murine macrophage cell lines can be ordered in a linear
RT   differentiation sequence.";
RL   Differentiation 32:157-164(1986).
//
RX   PubMed=16948499; DOI=10.1290/0510075.1;
RA   Cuetara B.L.V., Crotti T.N., O'Donoghue A.J., McHugh K.P.;
RT   "Cloning and characterization of osteoclast precursors from the
RT   RAW264.7 cell line.";
RL   In Vitro Cell. Dev. Biol. Anim. 42:182-188(2006).
//
RX   PubMed=19057837; DOI=10.1007/s00774-008-0018-6;
RA   Vincent C., Kogawa M., Findlay D.M., Atkins G.J.;
RT   "The generation of osteoclasts from RAW 264.7 precursors in defined,
RT   serum-free conditions.";
RL   J. Bone Miner. Metab. 27:114-119(2009).
//
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
//
RX   PubMed=22735334; DOI=10.1038/msb.2012.21;
RA   Bordbar A., Mo M.L., Nakayasu E.S., Schrimpe-Rutledge A.C., Kim Y.-M.,
RA   Metz T.O., Jones M.B., Frank B.C., Smith R.D., Peterson S.N.,
RA   Hyduke D.R., Adkins J.N., Palsson B.O.;
RT   "Model-driven multi-omic data analysis elucidates metabolic
RT   immunomodulators of macrophage activation.";
RL   Mol. Syst. Biol. 8:558-558(2012).
//
RX   PubMed=23430347; DOI=10.1007/s10616-013-9545-7;
RA   Almeida J.L., Hill C.R., Cole K.D.;
RT   "Mouse cell line authentication.";
RL   Cytotechnology 66:133-147(2014).
//
RX   PubMed=25277546; DOI=10.1186/1471-2164-15-847;
RA   Didion J.P., Buus R.J., Naghashfar Z., Threadgill D.W.,
RA   Morse H.C. III, Pardo-Manuel de Villena F.;
RT   "SNP array profiling of mouse cell lines identifies their strains of
RT   origin and reveals cross-contamination and widespread aneuploidy.";
RL   BMC Genomics 15:847.1-847.11(2014).
//
RX   PubMed=25504905; DOI=10.1002/pmic.201400431;
RA   Guo M.-M., Hartlova A.S., Dill B.D., Prescott A.R., Gierlinski M.,
RA   Trost M.;
RT   "High-resolution quantitative proteome analysis reveals substantial
RT   differences between phagosomes of RAW 264.7 and bone marrow derived
RT   macrophages.";
RL   Proteomics 15:3169-3174(2015).
//
RX   PubMed=29889899; DOI=10.1371/journal.pone.0198943;
RA   Taciak B., Bialasek M., Braniewska A., Sas Z., Sawicka P., Kiraga L.,
RA   Rygiel T., Krol M.;
RT   "Evaluation of phenotypic and functional stability of RAW 264.7 cell
RT   line through serial passages.";
RL   PLoS ONE 13:E0198943-E0198943(2018).
//
RX   PubMed=31220119; DOI=10.1371/journal.pone.0218412;
RA   Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S.,
RA   Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H.,
RA   Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B.,
RA   Natoli M., Bauer B.A., Gollin S.M., Lewis D.W., Reid Y.A.;
RT   "Interlaboratory study to validate a STR profiling method for
RT   intraspecies identification of mouse cell lines.";
RL   PLoS ONE 14:E0218412-E0218412(2019).
//
RX   PubMed=31947698; DOI=10.3390/ijms21020538;
RA   Mira-Pascual L., Tran A.N., Andersson G., Nareoja T., Lang P.;
RT   "A sub-clone of RAW264.7-cells form osteoclast-like cells capable of
RT   bone resorption faster than parental RAW264.7 through increased de
RT   novo expression and nuclear translocation of NFATc1.";
RL   Int. J. Mol. Sci. 21:538.1-538.19(2020).
//
RX   PubMed=33389257; DOI=10.1007/s10096-020-04106-0;
RA   Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.;
RT   "Culture of SARS-CoV-2 in a panel of laboratory cell lines,
RT   permissivity, and differences in growth profile.";
RL   Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021).
//