Home  |  Contact

Cellosaurus RCC4 (CVCL_0498)

[Text version]

Cell line name RCC4
Synonyms RCC-4
Accession CVCL_0498
Resource Identification Initiative To cite this cell line use: RCC4 (RRID:CVCL_0498)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Sequence variations Hemizygous for VHL p.Ser65Trp (c.194C>G) (PubMed=21258414).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.89
Native American0
East Asian, North3.32
East Asian, South0
South Asian0.27
European, North55.04
European, South39.47
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UY81 (RCC4/empty vector)CVCL_2706 (RCC4/VHL)CVCL_V610 (SLR24)
Category Cancer cell line
Publications

PubMed=10353251; DOI=10.1038/20459
Maxwell P.H., Wiesener M.S., Chang G.-W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J.
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
Nature 399:271-275(1999)

PubMed=21258414; DOI=10.1038/onc.2010.638
Perier A., Fregni G., Wittnebel S., Gad S., Allard M., Gervois N., Escudier B., Azzarone B., Caignard A.
Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma.
Oncogene 30:2622-2632(2011)

PubMed=22949125; DOI=10.1002/ijc.27822
Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)

PubMed=27993170; DOI=10.1186/s12943-016-0565-8
Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C., Czarnecka A.M.
Choosing the right cell line for renal cell cancer research.
Mol. Cancer 15:83-83(2016)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165-15165(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources CCLE; RCC4_KIDNEY
DepMap; ACH-001175
TOKU-E; 3632
Ontologies BTO; BTO:0005691
MCCL; MCC:0000395
Chemistry resources PharmacoDB; RCC4_1286_2019
Other Wikidata; Q54949463
Polymorphism and mutation databases Cosmic; 1352067
Cosmic; 1497327
Cosmic; 1751968
Cosmic; 2520642
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number15