ID   RCC4
AC   CVCL_0498
SY   RCC-4
DR   BTO; BTO:0005691
DR   MCCL; MCC:0000395
DR   cancercelllines; CVCL_0498
DR   Cell_Model_Passport; SIDM01851
DR   ChEMBL-Cells; CHEMBL4483144
DR   ChEMBL-Targets; CHEMBL4483279
DR   Cosmic; 1352067
DR   Cosmic; 1497327
DR   Cosmic; 1751968
DR   Cosmic; 2520642
DR   DepMap; ACH-001175
DR   PharmacoDB; RCC4_1286_2019
DR   Progenetix; CVCL_0498
DR   PubChem_Cell_line; CVCL_0498
DR   TOKU-E; 3632
DR   Wikidata; Q54949463
RX   PubMed=10353251;
RX   PubMed=21258414;
RX   PubMed=22949125;
RX   PubMed=27993170;
RX   PubMed=28489074;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Ser65Trp (c.194C>G); ClinVar=VCV000043597; Zygosity=Hemizygous (PubMed=10353251; PubMed=21258414).
CC   Genome ancestry: African=1.89%; Native American=0%; East Asian, North=3.32%; East Asian, South=0%; South Asian=0.27%; European, North=55.04%; European, South=39.47% (PubMed=30894373).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   PubMed=10353251; DOI=10.1038/20459;
RA   Maxwell P.H., Wiesener M.S., Chang G.-W., Clifford S.C., Vaux E.C.,
RA   Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J.;
RT   "The tumour suppressor protein VHL targets hypoxia-inducible factors
RT   for oxygen-dependent proteolysis.";
RL   Nature 399:271-275(1999).
//
RX   PubMed=21258414; DOI=10.1038/onc.2010.638;
RA   Perier A., Fregni G., Wittnebel S., Gad S., Allard M.,
RA   Gervois-Segain N., Escudier B.J., Azzarone B., Caignard A.;
RT   "Mutations of the von Hippel-Lindau gene confer increased
RT   susceptibility to natural killer cells of clear-cell renal cell
RT   carcinoma.";
RL   Oncogene 30:2622-2632(2011).
//
RX   PubMed=22949125; DOI=10.1002/ijc.27822;
RA   Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.;
RT   "Loss of PBRM1 expression is associated with renal cell carcinoma
RT   progression.";
RL   Int. J. Cancer 132:E11-E17(2013).
//
RX   PubMed=27993170; DOI=10.1186/s12943-016-0565-8;
RA   Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C.,
RA   Czarnecka A.M.;
RT   "Choosing the right cell line for renal cell cancer research.";
RL   Mol. Cancer 15:83.1-83.15(2016).
//
RX   PubMed=28489074; DOI=10.1038/ncomms15165;
RA   Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y.-Y.,
RA   Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C.,
RA   Hsieh J.J.-D., Hakimi A.A.;
RT   "Analysis of renal cancer cell lines from two major resources enables
RT   genomics-guided cell line selection.";
RL   Nat. Commun. 8:15165.1-15165.10(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//