ID   RIN-m5F
AC   CVCL_0501
AS   CVCL_2177
SY   RIN m5F; Rin-M-5F; Rin-m-5F; RIN-m 5F; RINm-5F; RINm5F; RIN-m clone 5F; RIN Cl-5F; RIN-5F; Rin-5F; RIN 5F; RIN5F; m5F; 5F
DR   BTO; BTO:0001185
DR   CLO; CLO_0008817
DR   CLO; CLO_0008819
DR   MCCL; MCC:0000398
DR   CLDB; cl4150
DR   ATCC; CRL-2058
DR   ATCC; CRL-11605
DR   BCRC; 60410
DR   CCRID; 1101RAT-PUMC000386
DR   CCRID; 4201RAT-CCTCC00223
DR   ECACC; 95090402
DR   IBRC; C10101
DR   Lonza; 1056
DR   NCBI_Iran; C526
DR   Wikidata; Q54950473
RX   DOI=10.1016/j.bej.2003.09.013;
RX   PubMed=2090331;
RX   PubMed=2156672;
RX   PubMed=2550270;
RX   PubMed=6129963;
RX   PubMed=6141566;
RX   PubMed=6295859;
RX   PubMed=8697299;
RX   PubMed=10417352;
RX   PubMed=22538498;
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11605.
CC   Characteristics: Secretes mainly insulin and little somatostatin (PubMed=6141566; PubMed=6295859).
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from sampling site: Pancreas; islets of Langerhans.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus
HI   CVCL_3584 ! RIN-m
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 18
RX   DOI=10.1016/j.bej.2003.09.013;
RA   Ogawa A., Terada S., Saito Y., Kimura T., Yamaguchi A., Miki M.;
RT   "CrmA and Bcl-2 protect a cell line derived from islet of Langerhans,
RT   RIN-5F from hypoxia-induced apoptosis.";
RL   Biochem. Eng. J. 20:209-215(2004).
RX   PubMed=2090331; DOI=10.1016/0922-3371(90)90097-G;
RA   Bartholomeusz R.K., Campbell I.L., Harrison L.C.;
RT   "A2B5-reactive ganglioside expression determines the differentiation
RT   stage and capacity of rat insulinoma (RIN) sublines.";
RL   Cell Differ. Dev. 32:39-46(1990).
RX   PubMed=2156672; DOI=10.1210/endo-126-4-1927;
RA   Bartholomeusz R.K., Campbell I.L., Harrison L.C.;
RT   "A2B5-reactive ganglioside expression is an index of differentiation
RT   in rat insulinoma (RIN) cells.";
RL   Endocrinology 126:1927-1933(1990).
RX   PubMed=2550270; DOI=10.1055/s-0029-1210869;
RA   Nielsen J.H.;
RT   "Mechanisms of pancreatic beta-cell growth and regeneration: studies
RT   on rat insulinoma cells.";
RL   Exp. Clin. Endocrinol. 93:277-285(1989).
RX   PubMed=6129963; DOI=10.1210/endo-112-3-1070;
RA   Oie H.K., Gazdar A.F., Minna J.D., Weir G.C., Baylin S.B.;
RT   "Clonal analysis of insulin and somatostatin secretion and L-dopa
RT   decarboxylase expression by a rat islet cell tumor.";
RL   Endocrinology 112:1070-1075(1983).
RX   PubMed=6141566; DOI=10.3181/00379727-175-41762;
RA   Bhathena S.J., Awoke S., Voyles N.R., Wilkins S.D., Recant L.,
RA   Oie H.K., Gazdar A.F.;
RT   "Insulin, glucagon, and somatostatin secretion by cultured rat islet
RT   cell tumor and its clones.";
RL   Proc. Soc. Exp. Biol. Med. 175:35-38(1984).
RX   PubMed=6295859; DOI=10.2337/diab.31.6.521;
RA   Bhathena S.J., Oie H.K., Gazdar A.F., Voyles N.R., Wilkins S.D.,
RA   Recant L.;
RT   "Insulin, glucagon, and somatostatin receptors on cultured cells and
RT   clones from rat islet cell tumor.";
RL   Diabetes 31:521-531(1982).
RX   PubMed=8697299;
RA   Poitout V., Olson L.K., Robertson R.P.;
RT   "Insulin-secreting cell lines: classification, characteristics and
RT   potential applications.";
RL   Diabetes Metab. 22:7-14(1996).
RX   PubMed=10417352; DOI=10.1042/bj3410847;
RA   Fiskerstrand C.E., Newey P., Ebrahimi B., Gerrard L., Harrison P.,
RA   McGregor G.P., Quinn J.P.;
RT   "Novel cell lines for the analysis of preprotachykinin A gene
RT   expression identify a repressor domain 3' of the major
RT   transcriptional start site.";
RL   Biochem. J. 341:847-852(1999).
RX   PubMed=22538498; DOI=10.1159/000338793;
RA   Grozinsky-Glasberg S., Shimon I., Rubinfeld H.;
RT   "The role of cell lines in the study of neuroendocrine tumors.";
RL   Neuroendocrinology 96:173-187(2012).