Cellosaurus RL95-2 (CVCL_0505)

Cell line name RL95-2
Synonyms RL-95-2; RL952; RL95
Accession CVCL_0505
Resource Identification Initiative To cite this cell line use: RL95-2 (RRID:CVCL_0505)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Doubling time: 22 hours (PubMed=1541432).
Microsatellite instability: Instable (MSI-high) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Endometrial adenosquamous carcinoma (NCIt: C114656)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11
D13S3178,12
D16S53911,13
D18S5110,14
D19S43315
D21S1128,29
D2S133822,23
D3S135814,16
D5S81810,11
D7S82010
D8S117910,14
FGA20,22
Penta D9
Penta E5,11
TH019,9.3
TPOX8
vWA16,20
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=6339371; DOI=10.1007/BF02618053
Way D.L., Grosso D.S., Davis J.R., Surwit E.A., Christian C.D.
Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture.
In Vitro 19:147-158(1983)

PubMed=1541432; DOI=10.1016/0090-8258(92)90045-K
Rantanen V., Grenman S.E., Kulmala J., Salmi T., Grenman R.
Radiation sensitivity of endometrial carcinoma in vitro.
Gynecol. Oncol. 44:217-222(1992)

PubMed=8123477; DOI=10.1038/bjc.1994.87
Rantanen V., Grenman S.E., Kulmala J., Grenman R.
Comparative evaluation of cisplatin and carboplatin sensitivity in endometrial adenocarcinoma cell lines.
Br. J. Cancer 69:482-486(1994)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-1671
BCRC; 60103
BCRJ; 0366
KCB; KCB 2013033YJ
Cell line databases/resources CCLE; RL952_ENDOMETRIUM
CCRID; 3142C0001000000119
Cosmic-CLP; 930082
GDSC; 930082
IGRhCellID; RL952
LINCS_LDP; LCL-1506
Ontologies BTO; BTO:0004491
CLO; CLO_0008830
EFO; EFO_0002320
MCCL; MCC:0000402
Biological sample resources BioSample; SAMN03473219
Chemistry resources ChEMBL-Cells; CHEMBL3308843
ChEMBL-Targets; CHEMBL2366168
Gene expression databases GEO; GSM374977
GEO; GSM375436
GEO; GSM844677
GEO; GSM887542
GEO; GSM888625
GEO; GSM1670382
Polymorphism and mutation databases Cosmic; 713477
Cosmic; 713489
Cosmic; 809132
Cosmic; 846175
Cosmic; 871556
Cosmic; 889117
Cosmic; 930082
Cosmic; 980637
Cosmic; 1007165
Cosmic; 1066226
Cosmic; 1070808
Cosmic; 1102377
Cosmic; 1177623
Cosmic; 1223487
Cosmic; 1576464
Cosmic; 1622899
Cosmic; 1696756
Cosmic; 2030481
Cosmic; 2301551