Cellosaurus SK-N-BE(2)-C (CVCL_0529)

Cell line name SK-N-BE(2)-C
Synonyms SK-N-BE(2)C; SK-N-BE-2c; SK-N-BE(2C); SK-N-BE2C; SK_N_BE2C; SKNBE2C; SKNBE(2c); BE(2)-C; BE(2)C; Be(2)C; BE2-C; BE2_C; Be2-C; BE2C; Be2C
Accession CVCL_0529
Resource Identification Initiative To cite this cell line use: SK-N-BE(2)-C (RRID:CVCL_0529)
Comments Part of: ENCODE project common cell types; tier 3.
From: Memorial Sloan-Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan-Kettering Cancer Center Office of Technology Development; SK1980-532.
Characteristics: Intermediate type (I-type) (PubMed=15720811).
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: SNP array analysis.
Sequence variations TP53 p.Cys135Phe (c.404G>T) (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0528 (SK-N-BE(2))
Children:
CVCL_V006 (BE(2)-C/ADR(5))CVCL_V007 (BE(2)-C/ACT(0.2))CVCL_V008 (BE(2)-C/CHC(1))
CVCL_V009 (BE(2)-C/CHCb)CVCL_V010 (BE(2)-C/CHCg)
Sex of cell Male
Age at sampling 1Y10M
Category Cancer cell line
STR profile Source(s): ATCC; ECACC

Markers:
AmelogeninX
CSF1PO10
D13S31711
D16S5399,11
D5S81812
D7S8209,10
TH016
TPOX11
vWA18
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/BE2-C_Myers_protocol.pdf
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-162.html
https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-n-be-2-c-human-neuroblastoma-cell-line
Publications

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2535691
Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=1985865; DOI=10.1002/ijc.2910470119
Lashford L.S., Hancock J.P., Kemshead J.T.
Meta-iodobenzylguanidine (mIBG) uptake and storage in the human neuroblastoma cell line SK-N-BE(2C).
Int. J. Cancer 47:105-109(1991)

PubMed=15720811; DOI=10.1593/neo.04310
Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=19147553; DOI=10.1158/0008-5472.CAN-08-1856
Michaelis M., Rothweiler F., Klassert D., von Deimling A., Weber K., Fehse B., Kammerer B., Doerr H.-W., Cinatl J. Jr.
Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.
Cancer Res. 69:416-421(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24466371; DOI=10.1593/tlo.13544
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cross-references
Cell line collections ATCC; CRL-2268
ECACC; 95011817
ICLC; HTL96018
NCBI_Iran; C577
Cell line databases/resources CLDB; cl413
CLDB; cl4334
IGRhCellID; BE2C
LINCS_LDP; LCL-1963
Ontologies BTO; BTO:0004782
CLO; CLO_0001915
CLO; CLO_0009053
EFO; EFO_0005725
MCCL; MCC:0000428
Biological sample resources BioSample; SAMN03471855
ENCODE; ENCBS271SFD
ENCODE; ENCBS403ENC
ENCODE; ENCBS427ENC
ENCODE; ENCBS982TUR
Gene expression databases GEO; GSM651567
GEO; GSM651568
GEO; GSM945241
GEO; GSM945283
GEO; GSM923434
GEO; GSM2371256
GEO; GSM2394383
Other Wikidata; Q54954443
Polymorphism and mutation databases Cosmic; 688061
Cosmic; 922659
Cosmic; 1162003
Cosmic; 1167421
Cosmic; 1526648
Proteomic databases PRIDE; PXD003596