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Cellosaurus SMMC-7721 (CVCL_0534)

[Text version]

Cell line name SMMC-7721
Synonyms SMMC 7721; SMMC7721; H7721; H-7721
Accession CVCL_0534
Secondary accession CVCL_B400
Resource Identification Initiative To cite this cell line use: SMMC-7721 (RRID:CVCL_0534)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706; PubMed=28807831). Originally thought to originate from a hepatocellular carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00554.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Miscellaneous: Formerly the CCRID database had 3 entries describing this cell line (3111C0001CCC000087, 3131C0001000700052, 3142C0001000000063). They were one of the sources for the STR profile of this entry.
Misspelling: SMMU-7721; Occasionally.
Misspelling: SMCC-7721; Occasionally.
Derived from sampling site: Uterus; cervix.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706

Markers:
AmelogeninX
CSF1PO10
D2S133817
D3S135815,18
D5S81811,12
D6S104318
D7S82012
D8S117912
D12S39120,25,26
D13S31713.3
D16S5399,10
D18S5116
D19S43313
D21S1127,28
FGA18,21
Penta D8,15
Penta E7,17
TH017
TPOX12
vWA16,18

Run an STR similarity search on this cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-587.html
http://iclac.org/wp-content/uploads/Cross-Contaminations_v11_distribution.xlsx
Publications

PubMed=12717835; DOI=10.3748/wjg.v9.i5.946
Ma X.-D., Ma X., Sui Y.-F., Wang W.-L., Wang C.-M.
Signal transduction of gap junctional genes, connexin32, connexin43 in human hepatocarcinogenesis.
World J. Gastroenterol. 9:946-950(2003)

PubMed=17552011; DOI=10.3748/wjg.v13.i18.2608
Feng Y., Tian Z.-M., Wan M.-X., Zheng Z.-B.
Protein profile of human hepatocarcinoma cell line SMMC-7721: identification and functional analysis.
World J. Gastroenterol. 13:2608-2614(2007)

PubMed=23505090; DOI=10.1002/hep.26402
Wang K., Lim H.Y., Shi S., Lee J., Deng S., Xie T., Zhu Z., Wang Y., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=28807831; DOI=10.1016/j.jhep.2017.08.002
Rebouissou S., Zucman-Rossi J., Moreau R., Qiu Z.-X., Hui L.-J.
Note of caution: contaminations of hepatocellular cell lines.
J. Hepatol. 67:896-897(2017)

Cross-references
Ontologies BTO; BTO:0003227
MCCL; MCC:0000433
Chemistry resources ChEMBL-Cells; CHEMBL3308059
ChEMBL-Targets; CHEMBL613831
Gene expression databases GEO; GSM501779
GEO; GSM936777
GEO; GSM1374884
Other Wikidata; Q54954976
Polymorphism and mutation databases Cosmic; 852773
Cosmic; 1060081
Cosmic; 1499248
Cosmic; 2773184
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number25