Cellosaurus SNB-19 (CVCL_0535)

Cell line name SNB-19
Synonyms SNB.19; SNB19
Accession CVCL_0535
Resource Identification Initiative To cite this cell line use: SNB-19 (RRID:CVCL_0535)
Comments Problematic cell line: Contaminated. Shown to be a U-251MG derivative (PubMed=20143388, PubMed=22570425).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: NCI60 cancer cell line panel.
Doubling time: 34.6 hours (NCI-DTP); ~24 hours (DSMZ).
Sequence variation: Homozygous for PTEN p.Glu242fs*15 (PubMed=17088437).
Sequence variation: Homozygous for TP53 p.Arg273His (PubMed=17088437).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Fluorescence phenotype profiling.
Omics: lncRNA expression profiling.
Omics: Metabolome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Astrocytoma (NCIt: C60781)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0021 (U-251MG)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; DSMZ; PubMed=19372543; PubMed=25877200

Markers:
AmelogeninX,Y (ATCC; DSMZ; PubMed=19372543)
X (PubMed=25877200)
CSF1PO11,12 (ATCC; DSMZ; PubMed=25877200)
12 (PubMed=19372543)
D13S31710,11
D16S53912
D18S5113
D19S43313,15
D21S1129
D2S133822,24
D3S135816,17
D5S81811,12
D7S82010,12 (ATCC; DSMZ; PubMed=25877200)
10 (PubMed=19372543)
D8S117913,15
FGA21 (PubMed=19372543)
21,25 (PubMed=25877200)
Penta D12
Penta E7,10
TH019.3
TPOX8
vWA16,18
Web pages https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
https://dtp.cancer.gov/discovery_development/nci-60/u251_snb-19.htm
https://strap.nci.nih.gov/celline_detail.php?sample_id=55
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-111.html
http://www.atcc.org/Products/Cells_and_Microorganisms/Cell_Lines/Misidentified_Cell_Lines.aspx
http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
Publications

PubMed=3121170
Gross J.L., Behrens D.L., Mullins D.E., Kornblith P.L., Dexter D.L.
Plasminogen activator and inhibitor activity in human glioma cells and modulation by sodium butyrate.
Cancer Res. 48:291-296(1988)

PubMed=2041050; DOI=10.1093/jnci/83.11.757
Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K., Vistica D.T., Hose C., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J., Boyd M.
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)

DOI=10.1016/B978-0-12-333530-2.50005-8
Nister M., Westermark B.
Human glioma cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

PubMed=10700174; DOI=10.1038/73432
Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P., Iyer V., Jeffrey S.S., Van de Rijn M., Waltham M., Pergamenschikov A., Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N., Botstein D., Brown P.O.
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)

PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433
Ikediobi O.N., Davies H., Bignell G.R., Edkins S., Stevens C., O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L., Buck G., Butler A., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Hunter C., Jenkinson A., Jones D., Kosmidou V., Lugg R., Menzies A., Mironenko T., Parker A., Perry J., Raine K., Richardson D., Shepherd R., Small A., Smith R., Solomon H., Stephens P., Teague J.W., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Reinhold W.C., Weinstein J.N., Stratton M.R., Futreal P.A., Wooster R.
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)

PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921
Lorenzi P.L., Reinhold W.C., Varma S., Hutchinson A.A., Pommier Y., Chanock S.J., Weinstein J.N.
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=22384151; DOI=10.1371/journal.pone.0032096
Lee J.-S., Kim Y.K., Kim H.J., Hajar S., Tan Y.L., Kang N.-Y., Ng S.H., Yoon C.N., Chang Y.-T.
Identification of cancer cell-line origins using fluorescence image-based phenomic screening.
PLoS ONE 7:E32096-E32096(2012)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=22628656; DOI=10.1126/science.1218595
Jain M., Nilsson R., Sharma S., Madhusudhan N., Kitami T., Souza A.L., Kafri R., Kirschner M.W., Clish C.B., Mootha V.K.
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Science 336:1040-1044(2012)

PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342
Abaan O.D., Polley E.C., Davis S.R., Zhu Y.J., Bilke S., Walker R.L., Pineda M., Gindin Y., Jiang Y., Reinhold W.C., Holbeck S.L., Simon R.M., Doroshow J.H., Pommier Y., Meltzer P.S.
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73:4372-4382(2013)

PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018
Moghaddas Gholami A., Hahne H., Wu Z., Auer F.J., Meng C., Wilhelm M., Kuster B.
Global proteome analysis of the NCI-60 cell line panel.
Cell Rep. 4:609-620(2013)

PubMed=24279929; DOI=10.1186/2049-3002-1-20
Dolfi S.C., Chan L.L.-Y., Qiu J., Tedeschi P.M., Bertino J.R., Hirshfield K.M., Oltvai Z.N., Vazquez A.
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.
Cancer Metab. 1:20-20(2013)

PubMed=24335698; DOI=10.1093/neuonc/not202
An Q., Fillmore H.L., Vouri M., Pilkington G.J.
Brain tumor cell line authentication, an efficient alternative to capillary electrophoresis by using a microfluidics-based system.
Neuro-oncol. 16:265-273(2014)

PubMed=24670534; DOI=10.1371/journal.pone.0092047
Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C.
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:E92047-E92047(2014)

PubMed=27377824; DOI=10.1038/sdata.2016.52
Mestdagh P., Lefever S., Volders P.-J., Derveaux S., Hellemans J., Vandesompele J.
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.
Sci. Data 3:160052-160052(2016)

PubMed=27807467; DOI=10.1186/s13100-016-0078-4
Zampella J.G., Rodic N., Yang W.R., Huang C.R.L., Welch J., Gnanakkan V.P., Cornish T.C., Boeke J.D., Burns K.H.
A map of mobile DNA insertions in the NCI-60 human cancer cell panel.
Mob. DNA 7:20-20(2016)

Cross-references
Cell line collections ATCC; CRL-2219 - Discontinued
DSMZ; ACC-325
JCRB; NIHS0294 - Discontinued
NCI-DTP; SNB-19
Cell line databases/resources CCLE; SNB19_CENTRAL_NERVOUS_SYSTEM
IGRhCellID; SNB19
LINCS_LDP; LCL-1363
SKY/M-FISH/CGH; 2822
Ontologies BTO; BTO:0003761
CLO; CLO_0009093
EFO; EFO_0002342
MCCL; MCC:0000434
Biological sample resources BioSample; SAMN03151977
BioSample; SAMN03471000
BioSample; SAMN03472567
Chemistry resources ChEMBL-Cells; CHEMBL3307552
ChEMBL-Targets; CHEMBL614164
Gene expression databases GEO; GSM2090
GEO; GSM50178
GEO; GSM50242
GEO; GSM326246
GEO; GSM750785
GEO; GSM799326
GEO; GSM799389
GEO; GSM847161
GEO; GSM844697
GEO; GSM887600
GEO; GSM888683
GEO; GSM1153396
GEO; GSM1181304
GEO; GSM1181321
GEO; GSM2124686
Polymorphism and mutation databases Cosmic; 875894
Cosmic; 897439
Cosmic; 905966
Cosmic; 974241
Cosmic; 1044249
Cosmic; 1092637
Cosmic; 1305361
Cosmic; 1312343
Cosmic; 1746950
Cosmic; 1998480
Cosmic; 2302333
Cosmic; 2367548
Cosmic; 2550361