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Cellosaurus SW1353 (CVCL_0543)

[Text version]

Cell line name SW1353
Synonyms SW-1353; SW 1353
Accession CVCL_0543
Resource Identification Initiative To cite this cell line use: SW1353 (RRID:CVCL_0543)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
From: Scott and White Clinic; Temple; USA.
Population: Caucasian.
Karyotypic information: Hyperdiploid, 47,XX,+7 (ATCC).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Ribosome profiling.
Omics: Secretome proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone; right humerus.
Sequence variations
  • Mutation; HGNC; 5383; IDH2; Simple; p.Arg172Ser (c.516G>C); Zygosity=Heterozygous (PubMed=22057234; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val203Leu (c.607G>C); ClinVar=VCV000482235; Zygosity=Heterozygous (PubMed=19787792; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.24
Native American0
East Asian, North2.24
East Asian, South0
South Asian0
European, North66.16
European, South31.35
Disease Primary central chondrosarcoma (NCIt: C7155)
Chondrosarcoma (ORDO: Orphanet_55880)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Genomics_Center_BCF_Technion; PubMed=19787792

Markers:
AmelogeninX
CSF1PO12
D1S165611,17.3
D2S44111,14
D2S133819,24
D3S135815,18
D5S81810,11
D7S8209,11
D8S117910,11
D10S124813,16
D12S39122,23
D13S31712,13
D16S53911,12
D18S5113,17
D19S43314
D21S1130,32.2
D22S104515,17
FGA22,23
Penta D10,11
Penta E12,14
SE3319,21
TH016,9
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

DOI=10.1007/978-94-011-3550-4_4
Hay R.J.
Development, availability and characterization of ATCC human and animal cell lines.
(In) Animal cell culture and production of biologicals; Sasaki R., Ikura K. (eds.); pp.27-39; Springer; Dordrecht (1991)

PubMed=15950496; DOI=10.1016/j.joca.2005.04.004
Gebauer M., Saas J., Sohler F., Haag J., Soder S., Pieper M., Bartnik E., Beninga J., Zimmer R., Aigner T.
Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1beta.
Osteoarthritis Cartilage 13:697-708(2005)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22057234; DOI=10.1038/ng.1004
Pansuriya T.C., van Eijk R., d'Adamo P., van Ruler M.A.J.H., Kuijjer M.L., Oosting J., Cleton-Jansen A.-M., van Oosterwijk J.G., Verbeke S.L.J., Meijer D., van Wezel T., Nord K.H., Sangiorgi L., Toker B., Liegl-Atzwanger B., San-Julian M., Sciot R., Limaye N., Kindblom L.-G., Daugaard S., Godfraind C., Boon L.M., Vikkula M., Kurek K.C., Szuhai K., French P.J., Bovee J.V.M.G.
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
Nat. Genet. 43:1256-1261(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H., Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; HTB-94
BCRC; 60548
BCRJ; 0382
CLS; 300440
ICLC; HTL99008
IZSLER; BS TCL 213
NCBI_Iran; C571
Cell line databases/resources CLO; CLO_0009186
CLO; CLO_0009210
MCCL; MCC:0000443
CLDB; cl4957
CCRID; 3101HUMTCHu128
Cell_Model_Passport; SIDM01766
DepMap; ACH-000418
IGRhCellID; SW1353
Lonza; 85
TOKU-E; 3213
Anatomy/cell type resources BTO; BTO:0002003
Biological sample resources BioSample; SAMN03472765
BioSample; SAMN10988195
Chemistry resources ChEMBL-Cells; CHEMBL3307462
ChEMBL-Targets; CHEMBL614944
PharmacoDB; SW1353_1525_2019
Encyclopedic resources Wikidata; Q54971078
Experimental variables resources EFO; EFO_0002360
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7466
GEO; GSM887666
GEO; GSM888758
GEO; GSM1670499
GEO; GSM1676319
GEO; GSM1701652
Polymorphism and mutation databases Cosmic; 923378
Cosmic; 1602475
Cosmic; 1992321
IARC_TP53; 27036
LiGeA; CCLE_285
Progenetix; CVCL_0543
Proteomic databases PRIDE; PXD012985
PRIDE; PXD024953
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number32