Cell line name | T98G | ||||||||||||||||||||||||||||||||||||
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Synonyms | T 98 G; T-98G; T98 G; T98-G | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_0556 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: T98G (RRID:CVCL_0556) | ||||||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: ENCODE project common cell types; tier 3. Doubling time: 40 hours (PubMed=25984343); ~28 hours (PBCF). Karyotypic information: Hyperpentaploid karyotype. Has almost twice as many chromosomes as its parental cell line (T98) (PubMed=222778). Microsatellite instability: Stable (MSS) (Sanger). Omics: Cell surface proteome. Omics: Deep exome analysis. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: HLA class I peptidome analysis by proteomics. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis. | ||||||||||||||||||||||||||||||||||||
Sequence variations | Mutation; IDH1; none detected (PubMed=19435942).PTEN p.Leu42Arg (c.125T>G) (PubMed=9090379; PubMed=10560660; PubMed=28464039).TP53 p.Met237Ile (c.711G>T) (ClinVar=VCV000634770) (PubMed=10416987; PubMed=14614447). | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=27412690
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Genome ancestry | Source: PubMed=30894373
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Disease | Glioblastoma (NCIt: C3058) Glioblastoma (ORDO: Orphanet_360) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Parent: CVCL_B368 (T98) | ||||||||||||||||||||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||||||||||||||||||||
Age at sampling | 61Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): ATCC; COG; Cosmic-CLP; ECACC; JCRB; KCLB; PubMed=22570425; PubMed=25877200; RCB; TKG Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/T98G https://physics.cancer.gov/docs/bioresource/brain/NCI-PBCF-CRL1690_T98G_SOP-508.pdf http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/t/cell-lines-detail-574.html | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=222778; DOI=10.1002/jcp.1040990107 PubMed=3413074; DOI=10.1073/pnas.85.16.6042 PubMed=9090379; DOI=10.1038/ng0497-356 DOI=10.1007/0-306-46861-1_11 PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x PubMed=10560660; DOI=10.1097/00005072-199911000-00007 PubMed=11414198; DOI=10.1007/s004320000207 PubMed=14614447; DOI=10.1038/sj.onc.1207198 PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x PubMed=18445040; DOI=10.1111/j.1742-4658.2008.06452.x PubMed=19435942; DOI=10.1215/15228517-2009-025 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=20587068; DOI=10.1186/1471-2407-10-339 PubMed=22460905; DOI=10.1038/nature11003 PubMed=22570425; DOI=10.1093/neuonc/nos072 PubMed=25984343; DOI=10.1038/sdata.2014.35 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=25894527; DOI=10.1371/journal.pone.0121314 PubMed=26496030; DOI=10.18632/oncotarget.6171 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=27412690; DOI=10.1074/mcp.M116.060350 PubMed=28464039; DOI=10.1371/journal.pone.0176683 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections | ATCC; CRL-1690
ECACC; 92090213 IZSLER; BS TCL 63 JCRB; IFO50303 JCRB; JCRB9041 KCLB; 21690 RCB; RCB1954 TKG; TKG 0471 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl4478
CLDB; cl4480 CLDB; cl4481 CLDB; cl4482 CCLE; T98G_CENTRAL_NERVOUS_SYSTEM Cell_Model_Passport; SIDM01171 CGH-DB; 154-1 Cosmic-CLP; 687586 DepMap; ACH-000571 LINCS_LDP; LCL-1357 | ||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0001583
CLO; CLO_0009236 CLO; CLO_0009258 CLO; CLO_0050636 EFO; EFO_0002085 MCCL; MCC:0000457 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN01821603
BioSample; SAMN01821719 BioSample; SAMN01821740 BioSample; SAMN03473051 BioSample; SAMN05292443 BioSample; SAMN07710005 BioSample; SAMN07710006 BioSample; SAMN07710007 BioSample; SAMN07710008 BioSample; SAMN07710009 BioSample; SAMN07710010 BioSample; SAMN07710011 BioSample; SAMN10988244 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307777
ChEMBL-Targets; CHEMBL614775 GDSC; 687586 PharmacoDB; T98G_1562_2019 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 GEO; GSM326205 GEO; GSM887687 GEO; GSM888779 GEO; GSM1374954 GEO; GSM1670523 GEO; GSM2113432 GEO; GSM2113433 GEO; GSM2113434 GEO; GSM2113435 | ||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q52609889 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 687586
Cosmic; 759898 Cosmic; 849847 Cosmic; 850740 Cosmic; 897444 Cosmic; 1175821 Cosmic; 1217675 Cosmic; 1294953 Cosmic; 1610748 Cosmic; 1746960 Cosmic; 2302325 Cosmic; 2367552 Cosmic; 2491103 Cosmic; 2516040 Cosmic; 2701088 Cosmic; 2731176 Cosmic; 2732519 IARC_TP53; 2574 LiGeA; CCLE_712 Progenetix; CVCL_0556 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD000589
PRIDE; PXD002192 PRIDE; PXD003790 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||||||
Version number | 32 |