Cellosaurus T98G (CVCL_0556)

Cell line name T98G
Synonyms T 98 G; T-98G; T98 G; T98-G
Accession CVCL_0556
Resource Identification Initiative To cite this cell line use: T98G (RRID:CVCL_0556)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ENCODE project common cell types; tier 3.
Doubling time: 40 hours (PubMed=25984343).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Has no IDH1 mutation (PubMed=19435942).
Omics: Cell surface proteome.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Glioblastoma (NCIt: C3058)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B368 (T98)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; COG; Cosmic-CLP; ECACC; JCRB; KCLB; PubMed=22570425; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31713
D16S53913
D18S5113,16
D19S43312,13
D21S1128,32.2
D2S133819,24
D3S135816
D5S81810,12
D7S8209,10
D8S117913,14
FGA21,22 (COG; KCLB)
21 (PubMed=22570425; PubMed=25877200)
Penta D10,11
Penta E16
TH017,9.3
TPOX8
vWA17,20
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/t/cell-lines-detail-574.html
Publications

PubMed=222778; DOI=10.1002/jcp.1040990107
Stein G.H.
T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro.
J. Cell. Physiol. 99:43-54(1979)

PubMed=3413074; DOI=10.1073/pnas.85.16.604
Pereira-Smith O.M., Smith J.R.
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x
Saigusa K., Hashimoto N., Tsuda H., Yokoi S., Maruno M., Yoshimine T., Aoyagi M., Ohno K., Imoto I., Inazawa J.
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Cancer Sci. 96:676-683(2005)

PubMed=18445040; DOI=10.1111/j.1742-4658.2008.06452.x
Kikuchi Y., Kakeya T., Nakajima O., Sakai A., Ikeda K., Yamaguchi N., Yamazaki T., Tanamoto K., Matsuda H., Sawada J., Takatori K.
Hypoxia induces expression of a GPI-anchorless splice variant of the prion protein.
FEBS J. 275:2965-2976(2008)

PubMed=19435942; DOI=10.1215/15228517-2009-025
Ichimura K., Pearson D.M., Kocialkowski S., Backlund L.M., Chan R., Jones D.T.W., Collins V.P.
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncol. 11:341-347(2009)

PubMed=20587068; DOI=10.1186/1471-2407-10-339
Nakabayashi H., Yawata T., Shimizu K.
Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells.
BMC Cancer 10:339-339(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=26496030; DOI=10.18632/oncotarget.6171
Patil V., Pal J., Somasundaram K.
Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing.
Oncotarget 6:43452-43471(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-1690
ECACC; 92090213
IFO; IFO50303
IZSLER; BS TCL 63
JCRB; JCRB9041
KCLB; 21690
RCB; RCB1954
TKG; TKG 0471
Cell line databases/resources CLDB; cl4478
CLDB; cl4480
CLDB; cl4481
CLDB; cl4482
CCLE; T98G_CENTRAL_NERVOUS_SYSTEM
CGH-DB; 154-1
Cosmic-CLP; 687586
GDSC; 687586
LINCS_LDP; LCL-1357
Ontologies BTO; BTO:0001583
CLO; CLO_0009236
CLO; CLO_0009258
CLO; CLO_0050636
EFO; EFO_0002085
MCCL; MCC:0000457
Biological sample resources BioSample; SAMN01821603
BioSample; SAMN01821719
BioSample; SAMN01821740
BioSample; SAMN03473051
Chemistry resources ChEMBL-Cells; CHEMBL3307777
ChEMBL-Targets; CHEMBL614775
Gene expression databases GEO; GSM326205
GEO; GSM887687
GEO; GSM888779
GEO; GSM1374954
GEO; GSM1670523
Polymorphism and mutation databases Cosmic; 687586
Cosmic; 759898
Cosmic; 849847
Cosmic; 850740
Cosmic; 897444
Cosmic; 1175821
Cosmic; 1217675
Cosmic; 1294953
Cosmic; 1610748
Cosmic; 1746960
Cosmic; 2302325
Cosmic; 2367552
Cosmic; 2491103
Cosmic; 2516040
Proteomic databases PRIDE; PXD000589
PRIDE; PXD002192