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Cellosaurus TF-1 (CVCL_0559)

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Cell line name TF-1
Synonyms TF1; MFD-1
Accession CVCL_0559
Resource Identification Initiative To cite this cell line use: TF-1 (RRID:CVCL_0559)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: LL-100 blood cancer cell line panel.
Characteristics: Proliferatively responsive to many growth factors.
Characteristics: IL3 or CSF2 dependent.
Doubling time: 39 +- 6 hours (PubMed=9096695); ~70 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone marrow.
Sequence variations CBFA2T3-ABHD12 gene fusion (PubMed=31160637).
Heterozygous for NRAS p.Gln61Pro (c.182A>C) (CCLE).
TP53 p.Ile251fs (c.752delT) (PubMed=1571549).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.64
Native American0.04
East Asian, North79.7
East Asian, South18.49
South Asian0
European, North0
European, South1.13
Disease Erythroleukemia (NCIt: C7152)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_KS74 (CellSensor irf1-bla TF1)CVCL_8059 (D2 [Human erythroleukemia])CVCL_8060 (D8)
CVCL_ZJ11 (LanthaScreen STAT5 TF-1)CVCL_J294 (TF-1 BCR/ABL)CVCL_UE10 (TF-1 IDH2 p.R140Q)
CVCL_3607 (TF-1.CN5a.1)CVCL_RM06 (TF-1/TPO)CVCL_3608 (TF-1a)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; CLS; DSMZ; ECACC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO13,14 (ATCC; PubMed=25877200)
13 (CCRID; CLS; DSMZ; ECACC)
D2S133819
D3S135815
D5S81813
D7S82012
D8S117911,15
D13S3178,9
D16S5399,12
D18S5113
D19S43314,16
D21S1130
FGA18,19
Penta D10,13
Penta E5,17
TH017,9
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=TF-1
http://www.cellresource.cn/fdetail.aspx?id=118
http://www.cellresource.cn/fdetail.aspx?id=707
http://www.cellresource.cn/fdetail.aspx?id=2126
Publications

PubMed=2656885; DOI=10.1002/stem.5530070202
Ihle J.N., Askew D.
Origins and properties of hematopoietic growth factor-dependent cell lines.
Int. J. Cell Cloning 7:68-91(1989)

PubMed=2663885; DOI=10.1002/jcp.1041400219
Kitamura T., Tange T., Terasawa T., Chiba S., Kuwaki T., Miyagawa K., Piao Y.-F., Miyazono K., Urabe A., Takaku F.
Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin.
J. Cell. Physiol. 140:323-334(1989)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Ishikawa F., Takaku F., Yazaki Y., Hirai H.
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Drexler H.G., Zaborski M., Quentmeier H.
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections ATCC; CRL-2003
BCRC; 60323
BCRJ; 0233 - Discontinued
CCTCC; GDC0196
CLS; 300434/p538_TF-1
DSMZ; ACC-334
ECACC; 93022307
ICLC; HTL05001
NCBI_Iran; C602
Cell line databases/resources CLDB; cl4503
CLDB; cl7163
CCLE; TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3111C0001CCC000118
CCRID; 3111C0002000000101
CCRID; 3131C0001000700139
Cell_Model_Passport; SIDM01470
DepMap; ACH-000387
LINCS_LDP; LCL-1077
Lonza; 1015
Ontologies BTO; BTO:0004760
CLO; CLO_0009325
CLO; CLO_0009326
MCCL; MCC:0000460
Biological sample resources BioSample; SAMN03470850
BioSample; SAMN10988443
Chemistry resources ChEMBL-Cells; CHEMBL3307972
ChEMBL-Targets; CHEMBL612552
GDSC; 1331044
PharmacoDB; TF1_1588_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM743414
GEO; GSM887704
GEO; GSM888797
GEO; GSM1374961
Other Wikidata; Q54972197
Polymorphism and mutation databases Cosmic; 787479
Cosmic; 919129
Cosmic; 924041
Cosmic; 975302
Cosmic; 1012123
Cosmic; 1127259
Cosmic; 1281355
Cosmic; 2089658
Cosmic; 2306240
IARC_TP53; 2197
LiGeA; CCLE_592
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number29