Cellosaurus U266B1 (CVCL_0566)

Cell line name U266B1
Synonyms U266-B1; U266 B1; U-266; U 266; U266; U266S; U266BL; U266 Bl; 266 Bl
Accession CVCL_0566
Resource Identification Initiative To cite this cell line use: U266B1 (RRID:CVCL_0566)
Comments Group: Hybridoma fusion partner cell line.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Characteristics: Produces IgE lambda.
Doubling time: 108-144 hours (PubMed=4104421); ~55 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Plasma cell myeloma (NCIt: C3242)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_9087 (36); CVCL_9088 (A6 [Human/mouse hybridoma]); CVCL_C833 (AF10); CVCL_J235 (FU-266); CVCL_4974 (SKO-007); CVCL_0015 (U-266/70); CVCL_0016 (U-266/84); CVCL_GZ72 (U266/ADM); CVCL_T031 (U266/velR); CVCL_C828 (U266R)
Originate from same individual CVCL_JA36 ! 255 Bm
CVCL_W412 ! U268
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; ECACC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12,13
D13S31712
D16S53910
D18S5112,14
D3S135817
D5S81811,12
D7S82011,12
D8S117913
FGA18
Penta D10,13
Penta E10,12
TH015,7
TPOX8
vWA17
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=4097745
Nilsson K., Bennich H., Johansson S.G.O., Ponten J.
Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient.
Clin. Exp. Immunol. 7:477-489(1970)

PubMed=4104421; DOI=10.1002/ijc.2910070303
Nilsson K.
Characteristics of established myeloma and lymphoblastoid cell lines derived from an E myeloma patient: a comparative study.
Int. J. Cancer 7:380-396(1971)

PubMed=2537114
Duperray C., Klein B., Durie B.G.M., Zhang X., Jourdan M., Poncelet P., Favier F., Vincent C., Brochier J., Lenoir G.M., Bataille R.
Phenotypic analysis of human myeloma cell lines.
Blood 73:566-572(1989)

PubMed=1643757; DOI=10.1016/0090-1229(92)90205-3
Renz H., Or R., Domenico J., Leung D.Y.M., Gelfand E.W.
Reciprocal regulatory effects of IL-4 on cell growth and immunoglobulin production in Ig-secreting human B-cell lines.
Clin. Immunol. Immunopathol. 64:233-241(1992)

PubMed=8943038; DOI=10.1073/pnas.93.24.13931
Bergsagel P.L., Chesi M., Nardini E., Brents L.A., Kirby S.L., Kuehl W.M.
Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma.
Proc. Natl. Acad. Sci. U.S.A. 93:13931-13936(1996)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=10087940; DOI=10.1016/S0165-4608(98)00157-5
Kuipers J., Vaandrager J.W., Weghuis D.O., Pearson P.L., Scheres J., Lokhorst H.M., Clevers H., Bast B.J.E.G.
Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines.
Cancer Genet. Cytogenet. 109:99-107(1999)

PubMed=10557056; DOI=10.1038/sj.leu.2401563
Yoshida S., Nakazawa N., Iida S., Hayami Y., Sato S., Wakita A., Shimizu S., Taniwaki M., Ueda R.
Detection of MUM1/IRF4-IgH fusion in multiple myeloma.
Leukemia 13:1812-1816(1999)

PubMed=10583232; DOI=10.1046/j.1365-2141.1999.01705.x
Puthier D., Derenne S., Barille S., Moreau P., Harousseau J.-L., Bataille R., Amiot M.
Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.
Br. J. Haematol. 107:392-395(1999)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=11157491
Chesi M., Brents L.A., Ely S.A., Bais C., Robbiani D.F., Mesri E.A., Kuehl W.M., Bergsagel P.L.
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Blood 97:729-736(2001)

PubMed=11429052; DOI=10.1111/j.1349-7006.2001.tb01142.x
Hanamura I., Iida S., Akano Y., Hayami Y., Kato M., Miura K., Harada S., Banno S., Wakita A., Kiyoi H., Naoe T., Shimizu S., Sonta S.-I., Nitta M., Taniwaki M., Ueda R.
Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations.
Jpn. J. Cancer Res. 92:638-644(2001)

PubMed=15215163; DOI=10.1016/S0002-9440(10)63276-2
Inoue J., Otsuki T., Hirasawa A., Imoto I., Matsuo Y., Shimizu S., Taniwaki M., Inazawa J.
Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.
Am. J. Pathol. 165:71-81(2004)

PubMed=16956823
Bataille R., Jego G., Robillard N., Barille-Nion S., Harousseau J.-L., Moreau P., Amiot M., Pellat-Deceunynck C.
The phenotype of normal, reactive and malignant plasma cells Identification of 'many and multiple myelomas' and of new targets for myeloma therapy.
Haematologica 91:1234-1240(2006)

PubMed=17171682; DOI=10.1002/gcc.20404
Lombardi L., Poretti G., Mattioli M., Fabris S., Agnelli L., Bicciato S., Kwee I., Rinaldi A., Ronchetti D., Verdelli D., Lambertenghi-Deliliers G., Bertoni F., Neri A.
Molecular characterization of human multiple myeloma cell lines by integrative genomics: insights into the biology of the disease.
Genes Chromosomes Cancer 46:226-238(2007)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011
Dib A., Gabrea A., Glebov O.K., Bergsagel P.L., Kuehl W.M.
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

PubMed=21173094; DOI=10.3324/haematol.2010.033456
Moreaux J., Klein B., Bataille R., Descamps G., Maiga S., Hose D., Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M., Pellat-Deceunynck C.
A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
Haematologica 96:574-582(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23074853; DOI=10.1134/S1990519X12050136
Turilova V.K., Smirnova T.D.
Karyotypic variability of human myeloma cell lines.
Tsitologiia 54:621-636(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; TIB-196
BCRC; 60437
BCRJ; 0240 - Discontinued
DSMZ; ACC-9
ECACC; 85051003
IZSLER; BS TCL 233
KCB; KCB 2013024YJ
NCBI_Iran; C151
Cell line databases/resources CLDB; cl4584
CLDB; cl4609
CCLE; U266B1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CGH-DB; 37-1
CGH-DB; 9155-4
Cosmic-CLP; 753615
GDSC; 753615
IGRhCellID; U266B1
LINCS_LDP; LCL-2050
Lonza; 807
Ontologies BTO; BTO:0001594
CLO; CLO_0009457
CLO; CLO_0009458
EFO; EFO_0001254
MCCL; MCC:0000471
Biological sample resources BioSample; SAMN01821605
BioSample; SAMN01821669
BioSample; SAMN03472935
Chemistry resources ChEMBL-Cells; CHEMBL3308535
ChEMBL-Targets; CHEMBL2366315
Gene expression databases GEO; GSM143345
GEO; GSM545498
GEO; GSM545499
GEO; GSM827442
GEO; GSM887721
GEO; GSM888815
GEO; GSM1374970
GEO; GSM1670556
Polymorphism and mutation databases Cosmic; 720795
Cosmic; 742953
Cosmic; 753615
Cosmic; 759903
Cosmic; 759912
Cosmic; 760401
Cosmic; 760647
Cosmic; 886087
Cosmic; 888019
Cosmic; 991555
Cosmic; 1424220
Cosmic; 1483078
Cosmic; 1762463
Cosmic; 1889513
Cosmic; 2081409
Cosmic; 2367281
Cosmic; 2391806