Cellosaurus WM35 (CVCL_0580)

Cell line name WM35
Synonyms WM-35; WM 35; WC00060
Accession CVCL_0580
Resource Identification Initiative To cite this cell line use: WM35 (RRID:CVCL_0580)
Comments Part of: Wistar Institute melanoma cell line collection.
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Heterozygous for BRAF p.Val600Glu (Wistar).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_A806 (WM35-P1N1); CVCL_A807 (WM35-P1N2); CVCL_A808 (WM35-P1N3); CVCL_A809 (WM35-P2N1); CVCL_A810 (WM35-P2N2); CVCL_A811 (WM35-P2N3)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=27087056; Wistar

Markers:
AmelogeninX
CSF1PO10
D13S31711
D16S53912,13
D18S5120
D19S43315,16
D21S1129,32.2
D2S133818,25
D3S135816,18
D5S81811,12
D7S82010,13
D8S117911,13
FGA19
TH019.3
TPOX8
vWA17
Publications

PubMed=2068080; DOI=10.1073/pnas.88.14.6028
Cornil I., Theodorescu D., Man S., Herlyn M., Jambrosic J.A., Kerbel R.S.
Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.
Proc. Natl. Acad. Sci. U.S.A. 88:6028-6032(1991)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=18790768; DOI=10.1158/1535-7163.MCT-08-0431
Smalley K.S.M., Lioni M., Dalla Palma M., Xiao M., Desai B., Egyhazi S., Hansson J., Wu H., King A.J., Van Belle P., Elder D.E., Flaherty K.T., Herlyn M., Nathanson K.L.
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Mol. Cancer Ther. 7:2876-2883(2008)

PubMed=23039341; DOI=10.1186/1476-4598-11-75
Byron S.A., Loch D.C., Wellens C.L., Wortmann A., Wu J., Wang J., Nomoto K., Pollock P.M.
Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status.
Mol. Cancer 11:75-75(2012)

PubMed=27087056; DOI=10.1038/srep24569
Haridas P., McGovern J.A., Kashyap A.S., McElwain D.L.S., Simpson M.J.
Standard melanoma-associated markers do not identify the MM127 metastatic melanoma cell line.
Sci. Rep. 6:24569-24569(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-2807 - Discontinued
Coriell; WC00060 - Discontinued
Cell line databases/resources Cosmic-CLP; 1299080
GDSC; 1299080
LINCS_LDP; LCL-1263
Lonza; 583
Ontologies BTO; BTO:0003475
CLO; CLO_0009617
MCCL; MCC:0000486
Biological sample resources BioSample; SAMN03471793
Gene expression databases GEO; GSM186484
GEO; GSM186485
GEO; GSM188068
GEO; GSM188120
GEO; GSM188193
GEO; GSM188208
GEO; GSM188213
GEO; GSM188284
GEO; GSM188293
GEO; GSM555188
GEO; GSM952586
GEO; GSM1670580
Polymorphism and mutation databases Cosmic; 686396
Cosmic; 886834
Cosmic; 1155548
Cosmic; 1187584
Cosmic; 1247866
Cosmic; 1303075
Cosmic; 1507600
Cosmic; 1995666
Cosmic; 2159431