ID   MCF-10A
AC   CVCL_0598
SY   MCF 10A; MCF.10A; MCF10A; MCF10-A; MCF10a; MCF-10 Attached; Michigan Cancer Foundation-10A
DR   BTO; BTO:0001939
DR   CLO; CLO_0007599
DR   EFO; EFO_0001200
DR   MCCL; MCC:0000305
DR   AddexBio; C0006015/4976
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-TABM-157
DR   ATCC; CRL-10317
DR   BCRJ; 0161
DR   BioSample; SAMN03471375
DR   CCRID; 3111C0001CCC000406
DR   CCRID; 3131C0001000200025
DR   ChEMBL-Cells; CHEMBL3307364
DR   ChEMBL-Targets; CHEMBL614321
DR   Cosmic; 1136376
DR   Cosmic; 1176649
DR   Cosmic; 2318371
DR   Cosmic; 2560254
DR   DepMap; ACH-001357
DR   ENCODE; ENCBS066ENC
DR   ENCODE; ENCBS067ENC
DR   ENCODE; ENCBS317EPD
DR   ENCODE; ENCBS417KGL
DR   ENCODE; ENCBS617ENC
DR   ENCODE; ENCBS618ENC
DR   ENCODE; ENCBS619ENC
DR   ENCODE; ENCBS620ENC
DR   ENCODE; ENCBS621ENC
DR   ENCODE; ENCBS622ENC
DR   ENCODE; ENCBS623ENC
DR   ENCODE; ENCBS868SSJ
DR   GEO; GSM50033
DR   GEO; GSM155217
DR   GEO; GSM320171
DR   GEO; GSM350543
DR   GEO; GSM498022
DR   GEO; GSM498026
DR   GEO; GSM756371
DR   GEO; GSM845395
DR   GEO; GSM844584
DR   GEO; GSM1053724
DR   GEO; GSM1172973
DR   GEO; GSM1172882
DR   GEO; GSM1238116
DR   GEO; GSM1328939
DR   GEO; GSM1328940
DR   GEO; GSM1328941
DR   GEO; GSM2862786
DR   GEO; GSM2862787
DR   GEO; GSM2862788
DR   IBRC; C10788
DR   IGRhCellID; MCF10A
DR   IZSLER; BS CL 174
DR   KCB; KCB 2014066YJ
DR   LINCS_HMS; 50583
DR   LINCS_LDP; LCL-2085
DR   Lonza; 131
DR   MetaboLights; MTBLS401
DR   MetaboLights; MTBLS669
DR   NCBI_Iran; C609
DR   PharmacoDB; MCF10A_891_2019
DR   PRIDE; PXD000309
DR   PRIDE; PXD000593
DR   PRIDE; PXD000691
DR   PRIDE; PXD003370
DR   PRIDE; PXD005339
DR   PRIDE; PXD009668
DR   TOKU-E; 2378
DR   Wikidata; Q54904280
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RX   Patent=US5436152;
RX   PubMed=1975513;
RX   PubMed=12661003;
RX   PubMed=15375546;
RX   PubMed=17157791;
RX   PubMed=19582160;
RX   PubMed=20169162;
RX   PubMed=22414580;
RX   PubMed=24009699;
RX   PubMed=24094812;
RX   PubMed=24162158;
RX   PubMed=24176112;
RX   PubMed=24262153;
RX   PubMed=25485619;
RX   PubMed=25960936;
RX   PubMed=26055192;
RX   PubMed=26218769;
RX   PubMed=28196595;
RX   PubMed=28287265;
RX   PubMed=28596718;
RX   PubMed=28889351;
RX   PubMed=29561695;
RX   PubMed=30787054;
WW   https://strap.nci.nih.gov/celline_detail.php?sample_id=81
WW   http://lincs.hms.harvard.edu/resources/reagents/icbp43/
WW   https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
WW   http://tcpaportal.org/mclp/
WW   http://www.cellresource.cn/fdetail.aspx?id=482
WW   http://www.cellresource.cn/fdetail.aspx?id=2025
CC   Part of: GrayJW breast cancer cell line panel.
CC   Part of: ICBP43 breast cancer cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Doubling time: 26.74 hours (https://www.synapse.org/#!Synapse:syn2347014).
CC   HLA typing: A*33:01,01:01; B*55:01,40:01; C*07:02,03:03; DQA1*03:02,02:01; DQB1*03:05,03:05; DRB1*04:02,11:44 (PubMed=25960936).
CC   Microsatellite instability: Stable (MSS) (PubMed=12661003).
CC   Omics: CNV analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Glycoproteome analysis by proteomics.
CC   Omics: Metabolome analysis.
CC   Omics: N-glycan profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
ST   Source(s): AddexBio; ATCC; CCRID; PubMed=25877200; PubMed=28889351
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D12S391: 17,20
ST   D13S317: 8,9
ST   D16S539: 11,12
ST   D18S51: 18,19
ST   D19S433: 13,15
ST   D21S11: 28,30
ST   D2S1338: 21,26
ST   D3S1358: 14,18
ST   D5S818: 10,13
ST   D6S1043: 12,18
ST   D7S820: 10,11
ST   D8S1179: 14,16
ST   FGA: 22,24
ST   Penta D: 10,12
ST   Penta E: 13,14
ST   TH01: 8,9.3
ST   TPOX: 9,11
ST   vWA: 15,17
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_3633 ! MCF-10F
SX   Female
AG   36Y
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 02-07-20; Version: 32
//
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RA   Leibovitz A.;
RT   "Cell lines from human breast.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York (1994).
//
RX   Patent=US5436152;
RA   Soule H.D., McGrath C.M.;
RT   "Immortal human mammary epithelial cell lines.";
RL   Patent number US5436152, 25-Jul-1995.
//
RX   PubMed=1975513;
RA   Soule H.D., Maloney T.M., Wolman S.R., Peterson W.D. Jr., Brenz R.,
RA   McGrath C.M., Russo J., Pauley R.J., Jones R.F., Brooks S.C.;
RT   "Isolation and characterization of a spontaneously immortalized human
RT   breast epithelial cell line, MCF-10.";
RL   Cancer Res. 50:6075-6086(1990).
//
RX   PubMed=12661003; DOI=10.1002/gcc.10196;
RA   Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U.,
RA   Santibanez-Koref M.-F., Schlag P.M., Scherneck S.;
RT   "Identification of microsatellite instability and mismatch repair gene
RT   mutations in breast cancer cell lines.";
RL   Genes Chromosomes Cancer 37:29-35(2003).
//
RX   PubMed=15375546; DOI=10.3892/ijo.25.4.961;
RA   Peng X., Yun D., Christov K.;
RT   "Breast cancer progression in MCF10A series of cell lines is
RT   associated with alterations in retinoic acid and retinoid X receptors
RT   and with differential response to retinoids.";
RL   Int. J. Oncol. 25:961-971(2004).
//
RX   PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008;
RA   Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T.,
RA   Clark L., Bayani N., Coppe J.P., Tong F., Speed T., Spellman P.T.,
RA   DeVries S., Lapuk A., Wang N.J., Kuo W.L., Stilwell J.L., Pinkel D.,
RA   Albertson D.G., Waldman F.M., McCormick F., Dickson R.B.,
RA   Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.;
RT   "A collection of breast cancer cell lines for the study of
RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//
RX   PubMed=19582160; DOI=10.1371/journal.pone.0006146;
RA   Kao J., Salari K., Bocanegra M., Choi Y.-L., Girard L., Gandhi J.,
RA   Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D.,
RA   Pollack J.R.;
RT   "Molecular profiling of breast cancer cell lines defines relevant
RT   tumor models and provides a resource for cancer gene discovery.";
RL   PLoS ONE 4:E6146-E6146(2009).
//
RX   PubMed=20169162; DOI=10.1371/journal.pone.0009201;
RA   Kadota M., Yang H.H., Gomez B., Sato M., Clifford R.J., Meerzaman D.,
RA   Dunn B.K., Wakefield L.M., Lee M.P.;
RT   "Delineating genetic alterations for tumor progression in the MCF10A
RT   series of breast cancer cell lines.";
RL   PLoS ONE 5:E9201-E9201(2010).
//
RX   PubMed=22414580; DOI=10.1158/0008-5472.CAN-11-3711;
RA   Geiger T., Madden S.F., Gallagher W.M., Cox J., Mann M.;
RT   "Proteomic portrait of human breast cancer progression identifies
RT   novel prognostic markers.";
RL   Cancer Res. 72:2428-2439(2012).
//
RX   PubMed=24009699; DOI=10.1371/journal.pone.0072704;
RA   Liu X., Nie H., Zhang Y.-B., Yao Y.-F., Maitikabili A., Qu Y.-P.,
RA   Shi S.-L., Chen C.-Y., Li Y.;
RT   "Cell surface-specific N-glycan profiling in breast cancer.";
RL   PLoS ONE 8:E72704-E72704(2013).
//
RX   PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020;
RA   Timmerman L.A., Holton T., Yuneva M., Louie R.J., Padro M., Daemen A.,
RA   Hu M., Chan D.A., Ethier S.P., van 't Veer L.J., Polyak K.,
RA   McCormick F., Gray J.W.;
RT   "Glutamine sensitivity analysis identifies the xCT antiporter as a
RT   common triple-negative breast tumor therapeutic target.";
RL   Cancer Cell 24:450-465(2013).
//
RX   PubMed=24162158; DOI=10.1007/s10549-013-2743-3;
RA   Prat A., Karginova O., Parker J.S., Fan C., He X., Bixby L.,
RA   Harrell J.C., Roman E., Adamo B., Troester M., Perou C.M.;
RT   "Characterization of cell lines derived from breast cancers and normal
RT   mammary tissues for the study of the intrinsic molecular subtypes.";
RL   Breast Cancer Res. Treat. 142:237-255(2013).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110;
RA   Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M.,
RA   Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S.,
RA   Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S.,
RA   Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J.,
RA   Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.;
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=24262153; DOI=10.1016/j.jprot.2013.11.006;
RA   Yen T.Y., Haste N., Timpe L.C., Litsakos-Cheung C., Yen R.,
RA   Macher B.A.;
RT   "Using a cell line breast cancer progression system to identify
RT   biomarker candidates.";
RL   J. Proteomics 96:173-183(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893;
RA   Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.;
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:E954893-E954893(2014).
//
RX   PubMed=26055192; DOI=10.1021/acs.jproteome.5b00375;
RA   Cifani P., Kirik U., Waldemarson S., James P.;
RT   "Molecular portrait of breast-cancer-derived cell lines reveals poor
RT   similarity with tumors.";
RL   J. Proteome Res. 14:2819-2827(2015).
//
RX   PubMed=26218769; DOI=10.1016/j.jchromb.2015.07.021;
RA   Willmann L., Schlimpert M., Halbach S., Erbes T., Stickeler E.,
RA   Kammerer B.;
RT   "Metabolic profiling of breast cancer: differences in central
RT   metabolism between subtypes of breast cancer cell lines.";
RL   J. Chromatogr. B 1000:95-104(2015).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P.,
RA   Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470;
RA   Yen T.-Y., Bowen S., Yen R., Piryatinska A., Macher B.A., Timpe L.C.;
RT   "Glycoproteins in claudin-low breast cancer cell lines have a unique
RT   expression profile.";
RL   J. Proteome Res. 16:1391-1400(2017).
//
RX   PubMed=28596718; DOI=10.1007/s11306-017-1213-z;
RA   Herman S., Emami Khoonsari P., Aftab O., Krishnan S., Strombom E.,
RA   Larsson R., Hammerling U., Spjuth O., Kultima K., Gustafsson M.;
RT   "Mass spectrometry based metabolomics for in vitro systems
RT   pharmacology: pitfalls, challenges, and computational solutions.";
RL   Metabolomics 13:79-79(2017).
//
RX   PubMed=28889351; DOI=10.1007/s10549-017-4496-x;
RA   Saunus J.M., Smart C.E., Kutasovic J.R., Johnston R.L.,
RA   Kalita-de Croft P., Miranda M., Rozali E.N., Vargas A.C., Reid L.E.,
RA   Lorsy E., Cocciardi S., Seidens T., McCart Reed A.E., Dalley A.J.,
RA   Wockner L.F., Johnson J., Sarkar D., Askarian-Amiri M.E.,
RA   Simpson P.T., Khanna K.K., Chenevix-Trench G., Al-Ejeh F.,
RA   Lakhani S.R.;
RT   "Multidimensional phenotyping of breast cancer cell lines to guide
RT   preclinical research.";
RL   Breast Cancer Res. Treat. 167:289-301(2018).
//
RX   PubMed=29561695; DOI=10.1080/15384047.2018.1449612;
RA   Chen Z., Ai L., Mboge M.Y., McKenna R., Frost C.J., Heldermon C.D.,
RA   Frost S.C.;
RT   "UFH-001 cells: a novel triple negative, CAIX-positive, human breast
RT   cancer model system.";
RL   Cancer Biol. Ther. 19:598-608(2018).
//
RX   PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132;
RA   Hooker S.E., Woods-Burnham L., Bathina M., Lloyd S.M., Gorjala P.,
RA   Mitra R., Nonn L., Kimbro K.S., Kittles R.;
RT   "Genetic ancestry analysis reveals misclassification of commonly used
RT   cancer cell lines.";
RL   Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019).
//