ID   Ku812F
AC   CVCL_0616
SY   KU812F; KU-812-F; KU-812F; KU 812F; KU812-F
DR   BTO; BTO:0003142
DR   CLO; CLO_0007127
DR   CLO; CLO_0050974
DR   CLO; CLO_0051002
DR   CLDB; cl3072
DR   ATCC; CRL-2101
DR   BioSample; SAMN01821695
DR   cancercelllines; CVCL_0616
DR   ECACC; 90071804
DR   JCRB; JCRB0104.2
DR   LINCS_LDP; LCL-1108
DR   RCB; RCB0497
DR   RCB; RCB3053
DR   TKG; TKG 0304
DR   Wikidata; Q54900696
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=3304457;
RX   PubMed=2540861;
RX   PubMed=11416159;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys132Arg (c.395A>G); ClinVar=VCV000376625; Zygosity=Homozygous (from parent cell line).
CC   Discontinued: RCB; RCB3053; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: Basophil progenitor cell; CL=CL_0000613.
ST   Source(s): ATCC; ECACC; Genomics_Center_BCF_Technion; JCRB; PubMed=11416159; RCB; TKG
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13
ST   D10S1248: 14
ST   D12S391: 17
ST   D13S317: 8
ST   D16S539: 9
ST   D18S51: 13
ST   D19S433: 13,14
ST   D1S1656: 16,18
ST   D21S11: 30,31.2
ST   D22S1045: 11
ST   D2S1338: 18
ST   D2S441: 11
ST   D3S1358: 15
ST   D5S818: 10
ST   D7S820: 12
ST   D8S1179: 11,15
ST   DYS391: 10
ST   FGA: 22,24
ST   Penta D: 12
ST   Penta E: 5,19
ST   TH01: 9
ST   TPOX: 12
ST   vWA: 15
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0379 ! Ku812
SX   Male
AG   38Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=3304457; DOI=10.1182/blood.V70.3.612.612;
RA   Fukuda T., Kishi K., Ohnishi Y., Shibata A.;
RT   "Bipotential cell differentiation of KU-812: evidence of a hybrid cell
RT   line that differentiates into basophils and macrophage-like cells.";
RL   Blood 70:612-619(1987).
//
RX   PubMed=2540861; DOI=10.1182/blood.V73.7.2003.2003;
RA   Nakazawa M., Mitjavila-Garcia M.-T., Debili N., Casadevall N.,
RA   Mayeux P., Rouyer-Fessard P., Dubart-Kupperschmitt A., Romeo P.-H.,
RA   Beuzard Y., Kishi K., Breton-Gorius J., Vainchenker W.;
RT   "KU 812: a pluripotent human cell line with spontaneous erythroid
RT   terminal maturation.";
RL   Blood 73:2003-2013(1989).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//