Cellosaurus cell line MDA-MB-435S (CVCL_0622)

• Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=19593635; DepMap).
  
• Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=19593635).
  
• Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (PubMed=19593635).
  
• Mutation; HGNC; 3373; EP300; Simple; p.Leu827Pro (c.2480T>C); Zygosity=Hemizygous (PubMed=10700188).
  
• Mutation; HGNC; 3373; EP300; Simple; p.Glu1013Gly (c.3038A>G); ClinVar=VCV000562024; Zygosity=Hemizygous (PubMed=10700188).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (PubMed=16541312; DepMap).
  

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PubMed=12354931; DOI=10.1136/mp.55.5.294
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PubMed=12661003; DOI=10.1002/gcc.10196
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PubMed=15677628; DOI=10.1093/carcin/bgi032
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PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
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PubMed=16541312; DOI=10.1007/s10549-006-9186-z
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PubMed=19593635; DOI=10.1007/s10549-009-0460-8
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PubMed=20070913; DOI=10.1186/1471-2407-10-15
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PubMed=22460905; DOI=10.1038/nature11003
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
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PubMed=23601657; DOI=10.1186/bcr3415
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miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
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PubMed=26589293; DOI=10.1186/s13073-015-0240-5
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PubMed=28940260; DOI=10.1002/ijc.31067
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Authentication of M14 melanoma cell line proves misidentification of MDA-MB-435 breast cancer cell line.
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PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
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An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
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PubMed=31068700; DOI=10.1038/s41586-019-1186-3
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Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)