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Cellosaurus MOLT-3 (CVCL_0624)

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Cell line name MOLT-3
Synonyms Molt-3; MOLT 3; Molt 3; MOLT3; Molt3
Accession CVCL_0624
Resource Identification Initiative To cite this cell line use: MOLT-3 (RRID:CVCL_0624)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 24-48 hours (CLS); ~40 hours (DSMZ).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for NOTCH1 p.Leu1600Pro (c.4799T>C) and p.Pro2514fs*4 (c.7541_7542delCT) (PubMed=15472075).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_S660 (MOLT-3/MTX.P-9)CVCL_S658 (MOLT-3/MTX10000)CVCL_S659 (MOLT-3/MTX200)
CVCL_S652 (MOLT-3/MTXt)CVCL_S653 (MOLT-3/TMQ200)CVCL_S655 (MOLT-3/TMQ2500)
CVCL_S656 (MOLT-3/TMQ800)CVCL_M774 (MOLT-3/Z29)CVCL_S661 (MOLT-3/ZD1694.C)
CVCL_S662 (MOLT-3/ZD1694.P9)CVCL_N031 (MOVP-3)
Originate from same individual CVCL_0013 ! MOLT-4
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): ATCC; CLS; COG; DSMZ; PubMed=25877200; RCB

11,12,13 (CLS; PubMed=25877200; RCB)
D3S135814,15,16,17 (COG)
15,16,17 (CLS; PubMed=25877200)
D5S81812 (ATCC; PubMed=25877200)
12,13 (CLS; DSMZ; RCB)
D7S8208,10 (ATCC; COG; PubMed=25877200)
7,8,9,10 (CLS)
7,8,10 (DSMZ)
7,8,9 (RCB)
D8S11799,13,14,15 (CLS; PubMed=25877200)
9,14,15 (COG)
D13S31712,13 (ATCC; CLS; COG; DSMZ; PubMed=25877200)
11,12,13 (RCB)
D16S53911,13,14 (ATCC; PubMed=25877200)
11,14,15 (CLS)
11,12,14 (COG)
11,14 (DSMZ)
10,11,13 (RCB)
D18S5112,13,16,17 (CLS)
13,17 (COG)
13,17,18 (PubMed=25877200)
D21S1129,30,31,32 (CLS)
29,30 (PubMed=25877200)
FGA19,21,25 (CLS)
22,24 (COG)
21,22,23,24 (PubMed=25877200)
Penta D8,13
Penta E14,16
vWA17 (ATCC; COG; PubMed=25877200)
17,18 (CLS; DSMZ; RCB)

Run an STR similarity search on this cell line
Web pages http://www.nibsc.org/Default.aspx?pageid=597&id=0010&theme=default

PubMed=4567231; DOI=10.1093/jnci/49.3.891
Minowada J., Onuma T., Moore G.E.
Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes.
J. Natl. Cancer Inst. 49:891-895(1972)

PubMed=4547172; DOI=10.1093/jnci/53.3.655
Huang C.C., Hou Y., Woods L.K., Moore G.E., Minowada J.
Cytogenetic study of human lymphoid T-cell lines derived from lymphocytic leukemia.
J. Natl. Cancer Inst. 53:655-660(1974)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=6600440; DOI=10.1007/BF02617996
Uittenbogaart C.H., Cantor Y., Fahey J.L.
Growth of human malignant lymphoid cell lines in serum-free medium.
In Vitro 19:67-72(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

Greenberg J.M., Gonzalez-Sarmiento R., Arthur D.C., Wilkowski C.W., Streifel B.J., Kersey J.H.
Immunophenotypic and cytogenetic analysis of Molt-3 and Molt-4: human T-lymphoid cell lines with rearrangement of chromosome 7.
Blood 72:1755-1760(1988)

Zhou M., Gu L., James C.D., He J., Yeager A.M., Smith S.D., Findley H.W.
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G., Uppenkamp M., Nowrousian M.R., Seeber S., Opalka B.
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11986953; DOI=10.1038/sj.leu.2402485
O'Donnell P.H., Guo W.-X., Reynolds C.P., Maurer B.J.
N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.
Leukemia 16:902-910(2002)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cell line collections ATCC; CRL-1552
BCRC; 60106
CLS; 300116/p2664_MOLT-3
ECACC; 90021901
NIH-ARP; 12187-387
RCB; RCB1164
Cell line databases/resources CLDB; cl3519
CLDB; cl3521
CLDB; cl3522
CLDB; cl3523
Cell_Model_Passport; SIDM00153
Ontologies BTO; BTO:0001081
CLO; CLO_0007824
CLO; CLO_0051008
EFO; EFO_0005265
Biological sample resources BioSample; SAMN03470846
BioSample; SAMN03471394
BioSample; SAMN03472164
BioSample; SAMN03473404
Chemistry resources ChEMBL-Cells; CHEMBL3307556
ChEMBL-Targets; CHEMBL614176
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM236793
GEO; GSM236829
Other Wikidata; Q54906351
Polymorphism and mutation databases Cosmic; 724815
Cosmic; 850193
Cosmic; 913410
Cosmic; 999756
Cosmic; 1191701
Cosmic; 1281377
Cosmic; 1524845
Cosmic; 2301561
Cosmic; 2361367
Cosmic; 2602923