Cellosaurus SK-NEP-1 (CVCL_0631)

Cell line name SK-NEP-1
Synonyms SKNEP-1; SKNEP1; SKNEP
Accession CVCL_0631
Resource Identification Initiative To cite this cell line use: SK-NEP-1 (RRID:CVCL_0631)
Comments Problematic cell line: Misidentified. Originally thought to be a Wilm's tumor cell line but shown to be from an Ewing sarcoma (PubMed=17154184).
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan-Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan-Kettering Cancer Center Office of Technology Development; SK2008-052.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Ewing sarcoma (NCIt: C4817)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP

Markers:
AmelogeninX
CSF1PO10
D13S31711
D16S53911
D18S5115,17
D21S1129,31
D3S135814,15
D5S81813
D7S8208,10
D8S117912
FGA24
Penta D11,12
Penta E7,18
TH018,9.3
TPOX8,11
vWA15,19
Web pages https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-nep-1-human-ewing-sarcoma-cell-line
http://tcpaportal.org/mclp/
Publications

DOI=10.1007/978-1-4757-1647-4_5
Fogh J., Trempe G.L.
New human tumor cell lines.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.115-159; Springer; New York (1975)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6244232
Williams R.D.
Human urologic cancer cell lines.
Invest. Urol. 17:359-363(1980)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=17154184; DOI=10.1002/pbc.21099
Smith M.A., Morton C.L., Phelps D., Girtman K., Neale G., Houghton P.J.
SK-NEP-1 and Rh1 are Ewing family tumor lines.
Pediatr. Blood Cancer 50:703-706(2008)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H., Wen X., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; HTB-48
CLS; 300341/p618_SK-NEP-1
IZSLER; BS TCL 61
Cell line databases/resources CLDB; cl4353
Cosmic-CLP; 909730
GDSC; 909730
IGRhCellID; SKNEP1
LINCS_LDP; LCL-1802
Ontologies CLO; CLO_0009055
EFO; EFO_0002337
Biological sample resources BioSample; SAMN03472745
Chemistry resources ChEMBL-Cells; CHEMBL3308141
ChEMBL-Targets; CHEMBL1075580
Gene expression databases GEO; GSM827180
GEO; GSM845556
GEO; GSM844692
GEO; GSM1670452
Polymorphism and mutation databases Cosmic; 688125
Cosmic; 909730
Cosmic; 1112129
Cosmic; 1196558
Cosmic; 2060801
Cosmic; 2228232
Cosmic; 2294587