Cellosaurus SW948 (CVCL_0632)

Cell line name SW948
Synonyms SW-948; SW 948
Accession CVCL_0632
Resource Identification Initiative To cite this cell line use: SW948 (RRID:CVCL_0632)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: KuDOS 95 cell line panel.
Part of: PI3K genetic alteration cell panel (ATCC TCP-1028).
From: Scott and White Clinic; Temple; Texas; USA.
Doubling time: 2-4 days (DSMZ).
Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=25926053; Sanger).
Sequence variation: APC p.Arg1114Ter (PubMed=24755471).
Sequence variation: KRAS p.Gln61Leu (PubMed=24755471).
Sequence variation: PIK3CA p.Glu542Lys (PubMed=24755471).
Sequence variation: SMAD4 p.Asp537Tyr (PubMed=24755471).
Omics: Deep exome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: N-glycan profiling.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: SW984; In Cosmic 1184094.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP; DSMZ; ECACC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D13S31710,11
D16S53911,12
D18S5119
D21S1125.2,29
D3S135816
D5S81811
D7S8209,11
D8S117912,14
FGA24
Penta D12
Penta E13
TH016,9.3
TPOX8,11
vWA16,18
Publications

PubMed=1000501
Leibovitz A., Stinson J.C., McCombs W.B. III, McCoy C.E., Mazur K.C., Mabry N.D.
Classification of human colorectal adenocarcinoma cell lines.
Cancer Res. 36:4562-4569(1976)

PubMed=7104989; DOI=10.1016/0165-4608(82)90076-0
Chen T.-R., Hay R.J., Macy M.L.
Karyotype consistency in human colorectal carcinoma cell lines established in vitro.
Cancer Genet. Cytogenet. 6:93-117(1982)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352
Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=12584437; DOI=10.1159/000068544
Melcher R., Koehler S., Steinlein C., Schmid M., Mueller C.R., Luehrs H., Menzel T., Scheppach W., Moerk H., Scheurlen M., Koehrle J., Al-Taie O.
Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway.
Cytogenet. Genome Res. 98:22-28(2002)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23272949; DOI=10.1186/1755-8794-5-66
Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66-66(2012)

PubMed=24042735; DOI=10.1038/oncsis.2013.35
Ahmed D., Eide P.W., Eilertsen I.A., Danielsen S.A., Eknaes M., Hektoen M., Lind G.E., Lothe R.A.
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2:E71-E71(2013)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

DOI=10.1101/092767
Roumeliotis T.I., Williams S.P., Goncalves E., Zamanzad G.F., Aben N., Michaut M., Schubert M., Wright J.C., Yang M., Alsinet C., Dienstmann R., Guinney J., Beltrao P., Brazma A., Stegle O., Adams D.J., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.
Genomic determinants of protein abundance variation in colorectal cancer cells.
bioRxiv 2016:092767-092767(2016)

PubMed=26537799; DOI=10.1074/mcp.M115.051235
Holst S., Deuss A.J.M., van Pelt G.W., van Vliet S.J., Garcia-Vallejo J.J., Koeleman C.A.M., Deelder A.M., Mesker W.E., Tollenaar R.A., Rombouts Y., Wuhrer M.
N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.
Mol. Cell. Proteomics 15:124-140(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CCL-237
BCRC; 60318
CLS; 300347/p455_SW-948
DSMZ; ACC-326
ECACC; 91030714
NCBI_Iran; C499
Cell line databases/resources CLDB; cl4449
CCLE; SW948_LARGE_INTESTINE
ColonAtlas; SW948
Cosmic-CLP; 909757
GDSC; 909757
IGRhCellID; SW948
LINCS_LDP; LCL-1187
Ontologies BTO; BTO:0001534
CLO; CLO_0009203
CLO; CLO_0009225
CLO; CLO_0009226
EFO; EFO_0002375
Biological sample resources BioSample; SAMN03473187
Chemistry resources ChEMBL-Cells; CHEMBL3308131
ChEMBL-Targets; CHEMBL1075598
Gene expression databases GEO; GSM206555
GEO; GSM513926
GEO; GSM514316
GEO; GSM741243
GEO; GSM784024
GEO; GSM887681
GEO; GSM888773
GEO; GSM1346894
GEO; GSM1374938
GEO; GSM1374939
GEO; GSM1448213
GEO; GSM1670516
Metabolomic databases MetaboLights; MTBLS227
Polymorphism and mutation databases Cosmic; 724850
Cosmic; 876721
Cosmic; 909757
Cosmic; 934565
Cosmic; 948832
Cosmic; 995395
Cosmic; 1043831
Cosmic; 1184094
Cosmic; 1223151
Cosmic; 1310941
Cosmic; 1312317
Cosmic; 1466824
Cosmic; 1479599
Cosmic; 1609501
Cosmic; 1676730
Cosmic; 1708413
Cosmic; 1803952
Cosmic; 1995657
Cosmic; 2302021