Cellosaurus RPK-1 (CVCL_0B31)

Cell line name RPK-1
Synonyms RPK1
Accession CVCL_0B31
Resource Identification Initiative To cite this cell line use: RPK-1 (RRID:CVCL_0B31)
Comments Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Omics: Transcriptome analysis.
Sequence variations KRAS p.Gly12Asp (PubMed=22490663).
TP53 p.Met273Ile (PubMed=22490663).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4717 (PK-1)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

Cross-references
Ontologies BTO; BTO:0005470
Gene expression databases GEO; GSM862565
GEO; GSM862567