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Cellosaurus INA-6.Tu1 (CVCL_0C40)

[Text version]
Cell line name INA-6.Tu1
Synonyms Tu1
Accession CVCL_0C40
Resource Identification Initiative To cite this cell line use: INA-6.Tu1 (RRID:CVCL_0C40)
Comments Population: Caucasian.
Characteristics: Produces IgG kappa.
Characteristics: IL6 dependent.
Characteristics: Derived from a tumor that grew in a SCID mouse.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys132Met (c.395A>T); ClinVar=VCV000376629; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln331Ter (c.991C>T); ClinVar=VCV000922893; Zygosity=Heterozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5209 (INA-6)
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
Publications

PubMed=19621390; DOI=10.1002/ijc.24758
Guenther A., Gordon S., Tiemann M., Burger R., Bakker F., Green J.R., Baum W., Roelofs A.J., Rogers M.J., Gramatzki M.
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.
Int. J. Cancer 126:239-246(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0C40
Encyclopedic resources Wikidata; Q54897701
Entry history
Entry creation10-Apr-2015
Last entry update05-Oct-2023
Version number14