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Cellosaurus HCC-3 (CVCL_0C57)

[Text version]
Cell line name HCC-3
Synonyms HCC.3; HCC3; AKH13
Accession CVCL_0C57
Secondary accession CVCL_0C55
Resource Identification Initiative To cite this cell line use: HCC-3 (RRID:CVCL_0C57)
Comments Omics: Deep exome analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Miscellaneous: Direct author submission of STR profile from Rohr-Udilova N.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Unspecified (PubMed=31063779).
Disease Hepatitis C infection (NCIt: C3098)
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0C49 ! MF-3
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135817,18
D5S81813
D7S82011
D8S117914,15
D13S3179,12
D16S53912
D18S5114,17
D21S1129
FGA20
Penta D9
Penta E7,13
TH017
TPOX11
vWA14,17

Run an STR similarity search on this cell line
Web pages https://lccl.zucmanlab.com/hcc/cellLines/HCC.3
Publications

PubMed=16809312; DOI=10.1128/JVI.00020-06
Metzl C., Mischek D., Salmons B., Gunzburg W.H., Renner M., Portsmouth D.
Tissue- and tumor-specific targeting of murine leukemia virus-based replication-competent retroviral vectors.
J. Virol. 80:7070-7078(2006)

PubMed=18594539; DOI=10.1038/sj.bjc.6604440
Sagmeister S., Eisenbauer M., Pirker C., Mohr T., Holzmann K., Zwickl H., Bichler C., Kandioler D., Wrba F., Mikulits W., Gerner C., Shehata M., Majdic O., Streubel B., Berger W., Micksche M., Zatloukal K., Schulte-Hermann R., Grasl-Kraupp B.
New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis.
Br. J. Cancer 99:151-159(2008)

PubMed=23887712; DOI=10.1038/ncomms3218
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0C57
TOKU-E; 3990
Encyclopedic resources Wikidata; Q54749093
Polymorphism and mutation databases Cosmic; 1628384
Cosmic; 2162535
Entry history
Entry creation10-Apr-2015
Last entry update05-Oct-2023
Version number10