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Cellosaurus A2EN (CVCL_0P36)

[Text version]
Cell line name A2EN
Synonyms DT-21
Accession CVCL_0P36
Resource Identification Initiative To cite this cell line use: A2EN (RRID:CVCL_0P36)
Comments Characteristics: Established as a model for sexually transmitted pathogens infection, pathogenesis and innate immune response studies (Kerafast=ELU101).
Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Uterus, cervix, endocervical epithelium; UBERON=UBERON_0012252.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 55Y
Category Transformed cell line
STR profile Source(s): Millipore

Markers:
AmelogeninX
CSF1PO12,13
D3S135815
D5S81811,13
D7S82011
D8S117912,16
D13S3179,13
D16S5399,11
D18S5114,18
D21S1129,32.2
FGA21
Penta D9,12
Penta E7,10
TH016
TPOX8,11
vWA17

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Publications

PubMed=18201283; DOI=10.1111/j.1600-0897.2007.00566.x
Herbst-Kralovetz M.M., Quayle A.J., Ficarra M., Greene S., Rose W.A. II, Chesson R., Spagnuolo R.A., Pyles R.B.
Quantification and comparison of Toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia.
Am. J. Reprod. Immunol. 59:212-224(2008)

PubMed=21943934; DOI=10.1016/j.jri.2011.08.002
Buckner L.R., Schust D.J., Ding J., Nagamatsu T., Beatty W., Chang T.L.-Y., Greene S.J., Lewis M.E., Ruiz B., Holman S.L., Spagnuolo R.A., Pyles R.B., Quayle A.J.
Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix.
J. Reprod. Immunol. 92:8-20(2011)

Cross-references
Cell line collections (Providers) ABM; T0595
Kerafast; ELU101
Millipore; SCC131
Encyclopedic resources Wikidata; Q54606622
Entry history
Entry creation10-Apr-2015
Last entry update05-Oct-2023
Version number16