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Cellosaurus THP-1(NCI) (CVCL_0R25)

[Text version]

Cell line name THP-1(NCI)
Synonyms THP-1NCI
Accession CVCL_0R25
Resource Identification Initiative To cite this cell line use: THP-1(NCI) (RRID:CVCL_0R25)
Comments Population: Japanese.
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Children:
CVCL_0R26 (THP-1(NCI)/DC-SIGN)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=14972530; DOI=10.1016/j.virol.2003.09.028
Wu L., Martin T.D., Carrington M., KewalRamani V.N.
Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.
Virology 318:17-23(2004)

Cross-references
Cell line collections HIVReagentProgram; ARP-9949
Other Wikidata; Q54972344
Entry history
Entry creation08-Jul-2015
Last entry update23-Sep-2021
Version number10