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Cellosaurus IOSE11 (CVCL_0T68)

Cell line name IOSE11
Synonyms iOSE11; IOE11; Immortalized Ovarian Surface Epithelial cells 11
Accession CVCL_0T68
Resource Identification Initiative To cite this cell line use: IOSE11 (RRID:CVCL_0T68)
Comments Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: STR profile from personal communication of Monteiro A.N.A.
Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C3MB (IOSE11 p53R175H)CVCL_YZ54 (IOSE11CMYC)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10,12
D3S135816,17
D5S81811
D7S8208,10
D8S117911,15
D13S31711,12
D16S53910,11
D18S5113,14
D21S1129
FGA20,22
Penta D8,16
Penta E14,18
TH016,7
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=20360942; DOI=10.1593/neo.91948
Lawrenson K., Grun B., Benjamin E., Jacobs I.J., Dafou D., Gayther S.A.
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer.
Neoplasia 12:317-325(2010)

PubMed=21859834; DOI=10.1093/carcin/bgr140
Lawrenson K., Sproul D., Grun B., Notaridou M., Benjamin E., Jacobs I.J., Dafou D., Sims A.H., Gayther S.A.
Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.
Carcinogenesis 32:1540-1549(2011)

PubMed=25204737; DOI=10.1002/ijc.29197
Lawrenson K., Mhawech-Fauceglia P., Worthington J., Spindler T.J., O'Brien D., Lee J.M., Spain G., Sharifian M., Wang G.-S., Darcy K.M., Pejovic T., Sowter H., Timms J.F., Gayther S.A.
Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis.
Int. J. Cancer 137:1806-1817(2015)

PubMed=25804953; DOI=10.1093/hmg/ddv101
Coetzee S.G., Shen H.C., Hazelett D.J., Lawrenson K., Kuchenbaecker K., Tyrer J.P., Rhie S.K., Levanon K., Karst A.M., Drapkin R.I., Ramus S.J., Couch F.J., Offit K., Chenevix-Trench G., Monteiro A.N.A., Antoniou A., Freedman M.L., Coetzee G.A., Pharoah P.D.P., Noushmehr H., Gayther S.A.
Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.
Hum. Mol. Genet. 24:3595-3607(2015)

PubMed=29844388; DOI=10.1038/s41598-018-26670-4
Gjyshi A., Dash S., Cen L., Cheng C.-H., Zhang C.-M., Yoder S.J., Teer J.K., Armaiz-Pena G.N., Monteiro A.N.A.
Early transcriptional response of human ovarian and fallopian tube surface epithelial cells to norepinephrine.
Sci. Rep. 8:8291-8291(2018)

PubMed=30487138; DOI=10.1158/0008-5472.CAN-17-3864
Buckley M.A., Woods N.T., Tyrer J.P., Mendoza-Fandino G., Lawrenson K., Hazelett D.J., Najafabadi H.S., Gjyshi A., Carvalho R.S., Lyra P.C. Jr., Coetzee S.G., Shen H.C., Yang A.W., Earp M.A., Yoder S.J., Risch H., Chenevix-Trench G., Ramus S.J., Phelan C.M., Coetzee G.A., Noushmehr H., Hughes T.R., Sellers T.A., Goode E.L., Pharoah P.D.P., Gayther S.A., Monteiro A.N.A.
Functional analysis and fine mapping of the 9p22.2 ovarian cancer susceptibility locus.
Cancer Res. 79:467-481(2019)

PubMed=34253763; DOI=10.1038/s41598-021-93506-z
Dash S., Yoder S.J., Mesa T., Smith A., Cen L., Eschrich S.A., Armaiz-Pena G.N., Monteiro A.N.A.
Effects of long-term norepinephrine treatment on normal immortalized ovarian and fallopian tube cells.
Sci. Rep. 11:14334-14334(2021)

Cross-references
Encyclopedic resources Wikidata; Q54897912
Gene expression databases GEO; GSM1663032
GEO; GSM1663033
GEO; GSM1663034
GEO; GSM1663035
GEO; GSM1663036
GEO; GSM1663037
GEO; GSM1663038
GEO; GSM1663039
GEO; GSM2889281
GEO; GSM2889282
GEO; GSM2889283
GEO; GSM2889284
GEO; GSM2889285
GEO; GSM2889286
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number11