Cell line name |
CEM/MX1 |
Accession |
CVCL_0U11 |
Resource Identification Initiative |
To cite this cell line use: CEM/MX1 (RRID:CVCL_0U11) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0207 (CCRF-CEM) |
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
STR profile |
Source(s): ATCC
Markers:Amelogenin | X |
CSF1PO | 10,11,13,14 |
D5S818 | 11,12 |
D7S820 | 9,11,12,13 |
D13S317 | 8,11,12 |
D16S539 | 10,11,13 |
TH01 | 6,7,8 |
TPOX | 8,11 |
vWA | 16,18,19 |
Run an STR similarity search on this cell line |
Cross-references |
Cell line collections (Providers) |
ATCC; CRL-2259 - Discontinued
|
Cell line databases/resources |
cancercelllines; CVCL_0U11
|
Biological sample resources |
BioSample; SAMN03471852
|
Encyclopedic resources |
Wikidata; Q54809279
|
Entry history |
Entry creation | 08-Jul-2015 |
Last entry update | 05-Oct-2023 |
Version number | 18 |
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