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Cellosaurus 22Rv1 (CVCL_1045)

[Text version]

Cell line name 22Rv1
Synonyms 22RV1; 22Rv-1; 22rV1; CWR22-Rv1; CWR22R-V1; CWR22-R1; CWR22Rv1; CWR22R
Accession CVCL_1045
Resource Identification Initiative To cite this cell line use: 22Rv1 (RRID:CVCL_1045)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~49 hours (PubMed=10462204); 55 hours (PubMed=25984343); 63 hours (from cell counting), 94 hours (from absorbance) (DOI=10.5897/IJBMBR2013.0154); 40 hours (ATCC); 40-60 hours (DSMZ); ~41 hours (PBCF).
Microsatellite instability: Instable (MSI-high) (PubMed=23671654; Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Deep RNAseq analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for TP53 p.Gln331Arg (c.992A>G) (ATCC; PubMed=14518029).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.89
Native American0.23
East Asian, North0.52
East Asian, South0
South Asian0.27
European, North67.46
European, South30.62
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3967 (CWR22)
Children:
CVCL_4Y35 (22Rv1 R)CVCL_RS39 (22RV1rYM155_300nM)CVCL_KS53 (CellSensor Gli-bla 22Rv1)
CVCL_WK44 (CWR22Rv1-AR-EK)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; ECACC; PubMed=14518029; PubMed=25877200; PubMed=27271795; PubMed=31006810

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135814,15 (PubMed=14518029)
15 (PubMed=25877200; PubMed=27271795)
D5S81811,12,13 (ATCC; DSMZ; PubMed=14518029)
11,12 (Cosmic-CLP; ECACC; PubMed=31006810)
11,13 (PubMed=25877200; PubMed=27271795)
D7S8209,10,11 (ATCC; DSMZ; PubMed=25877200; PubMed=27271795)
10,11 (Cosmic-CLP; ECACC; PubMed=14518029; PubMed=31006810)
D8S117912,13,14 (PubMed=14518029; PubMed=27271795)
13,14 (PubMed=25877200)
D13S3178,9,12 (PubMed=14518029)
9,12 (PubMed=25877200; PubMed=27271795; PubMed=31006810)
D16S53912
D18S5113,14
D21S1130
FGA20,23
Penta D9,12
Penta E5,13
TH016,9.3
TPOX8
vWA15,21 (ATCC; Cosmic-CLP; DSMZ; ECACC; PubMed=25877200; PubMed=27271795; PubMed=31006810)
15,20,21 (PubMed=14518029)

Run an STR similarity search on this cell line
Web pages https://physics.cancer.gov/docs/bioresource/prostate/NCI-PBCF-CRL2505_22Rv1_SOP-508.pdf
https://web.archive.org/web/20160703200709/http://capcelllines.ca:80/details.asp?id=53
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-524.html
http://www.cellresource.cn/fdetail.aspx?id=668
Publications

PubMed=10462204; DOI=10.1007/s11626-999-0115-4
Sramkoski R.M., Pretlow T.G. II, Giaconia J.M., Pretlow T.P., Schwartz S., Sy M.-S., Marengo S.R., Rhim J.S., Zhang D., Jacobberger J.W.
A new human prostate carcinoma cell line, 22Rv1.
In Vitro Cell. Dev. Biol. Anim. 35:403-409(1999)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=15486987; DOI=10.1002/pros.20158
Zhao H., Kim Y., Wang P., Lapointe J., Tibshirani R., Pollack J.R., Brooks J.D.
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

DOI=10.5897/IJBMBR2013.0154
Iloki Assanga S.B., Gil-Salido A.A., Lewis Lujan L.M., Rosas-Durazo A., Acosta-Silva A.L., Rivera-Castaneda E.G., Rubio-Pino J.L.
Cell growth curves for different cell lines and their relationship with biological activities.
Int. J. Biotechnol. Mol. Biol. Res. 4:60-70(2013)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27271795; DOI=10.1002/pros.23190
Shourideh M., DePriest A., Mohler J.L., Wilson E.M., Koochekpour S.
Characterization of fibroblast-free CWR-R1ca castration-recurrent prostate cancer cell line.
Prostate 76:1067-1077(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132
Hooker S.E., Woods-Burnham L., Bathina M., Lloyd S.M., Gorjala P., Mitra R., Nonn L., Kimbro K.S., Kittles R.
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 0:0-0(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31006810; DOI=10.1093/nar/gkz286
Kounatidou E., Nakjang S., McCracken S.R.C., Dehm S.M., Robson C.N., Jones D., Gaughan L.
A novel CRISPR-engineered prostate cancer cell line defines the AR-V transcriptome and identifies PARP inhibitor sensitivities.
Nucleic Acids Res. 47:0-0(2019)

Cross-references
Cell line collections ATCC; CRL-2505
BCRC; 60545
CCTCC; GDC0288
DSMZ; ACC-438
ECACC; 05092802
KCB; KCB 200731YJ
Cell line databases/resources CCLE; 22RV1_PROSTATE
CCRID; 3131C0001000700100
Cell_Model_Passport; SIDM00499
Cosmic-CLP; 924100
GDSC; 924100
IGRhCellID; 22Rv1
LINCS_LDP; LCL-1145
Lonza; 1442
Ontologies BTO; BTO:0002999
CLO; CLO_0001199
CLO; CLO_0001200
EFO; EFO_0002095
Biological sample resources BioSample; SAMN03471600
BioSample; SAMN03472052
BioSample; SAMN05292447
BioSample; SAMN07710012
BioSample; SAMN07710013
BioSample; SAMN07710014
BioSample; SAMN07710015
BioSample; SAMN07710016
BioSample; SAMN07710017
BioSample; SAMN07710018
Chemistry resources ChEMBL-Cells; CHEMBL3308004
ChEMBL-Targets; CHEMBL612657
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM91926
GEO; GSM525793
GEO; GSM648815
GEO; GSM827396
GEO; GSM886837
GEO; GSM887900
GEO; GSM1374375
GEO; GSM1669565
Other Wikidata; Q54583380
Polymorphism and mutation databases Cosmic; 924100
Cosmic; 1075276
Cosmic; 1028699
Cosmic; 1071480
Cosmic; 1172629
Cosmic; 1330911
Cosmic; 1689707
Cosmic; 1995323
Cosmic; 2537791
Cosmic; 2580126
Cosmic; 2651766
Cosmic; 2669170
IARC_TP53; 18887
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number29