Cellosaurus 769-P (CVCL_1050)

Cell line name 769-P
Synonyms 769P; 769-p
Accession CVCL_1050
Resource Identification Initiative To cite this cell line use: 769-P (RRID:CVCL_1050)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Doubling time: 35 hours (PubMed=721102).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Renal cell carcinoma (NCIt: C9385)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D13S31710,14
D16S5399,13
D18S5114,17
D21S1128,30
D3S135816
D5S81812
D7S82010,11
D8S117912,16
FGA20,22
Penta D12,16
Penta E7,18
TH016,9.3
TPOX8,11
vWA18
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=1010528; DOI=10.1007/BF02797460
Williams R.D., Elliott A.Y., Stein N., Fraley E.E.
In vitro cultivation of human renal cell cancer. I. Establishment of cells in culture.
In Vitro 12:623-627(1976)

PubMed=721102; DOI=10.1007/BF02617972
Williams R.D., Elliott A.Y., Stein N., Fraley E.E.
In vitro cultivation of human renal cell cancer. II. Characterization of cell lines.
In Vitro 14:779-786(1978)

PubMed=6244232
Williams R.D.
Human urologic cancer cell lines.
Invest. Urol. 17:359-363(1980)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27993170; DOI=10.1186/s12943-016-0565-8
Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C., Czarnecka A.M.
Choosing the right cell line for renal cell cancer research.
Mol. Cancer 15:83-83(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-1933
CLS; 300106/p490_769-P
IZSLER; BS TCL 123
KCB; KCB 2013031YJ
Cell line databases/resources CCLE; 769P_KIDNEY
CCRID; 3111C0001CCC000333
CCRID; 3131C0001001200020
CCRID; 3142C0001000000087
Cosmic-CLP; 910922
GDSC; 910922
IGRhCellID; 769P
LINCS_LDP; LCL-1772
Ontologies CLO; CLO_0001485
EFO; EFO_0002099
Biological sample resources BioSample; SAMN03473275
Chemistry resources ChEMBL-Cells; CHEMBL3308705
ChEMBL-Targets; CHEMBL1075385
Gene expression databases GEO; GSM374479
GEO; GSM827256
GEO; GSM886844
GEO; GSM887908
GEO; GSM1669571
Polymorphism and mutation databases Cosmic; 687935
Cosmic; 801355
Cosmic; 910922
Cosmic; 982280
Cosmic; 1779197
Cosmic; 2520640