Cellosaurus A-427 (CVCL_1055)

Cell line name A-427
Synonyms A427
Accession CVCL_1055
Resource Identification Initiative To cite this cell line use: A-427 (RRID:CVCL_1055)
Comments Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Doubling time: 28 hours (in RPMI 1640+10% FBS), 38 hours (in ACL-3), 42 hours (in ACL-3+BSA) (PubMed=3940644); ~60-70 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CLS; Cosmic-CLP; DSMZ; KCLB; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31711,12
D16S53911,13
D18S5112
D21S1131.2
D3S135816
D5S81812
D7S8208,12
D8S117912,13
FGA18
Penta D13
Penta E15,17
TH019
TPOX8,11
vWA17
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=4357758; DOI=10.1093/jnci/51.5.1417
Giard D.J., Aaronson S.A., Todaro G.J., Arnstein P., Kersey J.H., Dosik H., Parks W.P.
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.
J. Natl. Cancer Inst. 51:1417-1423(1973)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3940644
Brower M., Carney D.N., Oie H.K., Gazdar A.F., Minna J.D.
Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium.
Cancer Res. 46:798-806(1986)

PubMed=3945555; DOI=10.1093/nar/14.2.843
Valenzuela D.M., Groffen J.
Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene.
Nucleic Acids Res. 14:843-852(1986)

PubMed=10908148; DOI=10.1038/labinvest.3780108
Speicher M.R., Petersen S., Uhrig S., Jentsch I., Fauth C., Eils R., Petersen I.
Analysis of chromosomal alterations in non-small cell lung cancer by multiplex-FISH, comparative genomic hybridization, and multicolor bar coding.
Lab. Invest. 80:1031-1041(2000)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003
Grundner-Culemann K., Dybowski J.N., Klammer M., Tebbe A., Schaab C., Daub H.
Comparative proteome analysis across non-small cell lung cancer cell lines.
J. Proteomics 130:1-10(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections AddexBio; C0016004/21
ATCC; CRL-7906 - Discontinued
ATCC; HTB-53
CLS; 300111/p760_A-427
DSMZ; ACC-234
IZSLER; BS TCL 120
KCLB; 30053
Cell line databases/resources CLDB; cl152
CLDB; cl153
CLDB; cl5024
CCRID; 3111C0001CCC000213
Cosmic-CLP; 910851
GDSC; 910851
IGRhCellID; A427
LINCS_LDP; LCL-1600
Ontologies BTO; BTO:0003770
CLO; CLO_0001590
EFO; EFO_0002104
Biological sample resources BioSample; SAMN01821535
BioSample; SAMN01821613
BioSample; SAMN03471087
Chemistry resources ChEMBL-Cells; CHEMBL3307775
ChEMBL-Targets; CHEMBL614515
ChEMBL-Targets; CHEMBL1075389
Gene expression databases GEO; GSM206444
GEO; GSM274755
GEO; GSM274756
GEO; GSM353235
GEO; GSM434323
GEO; GSM784204
GEO; GSM827284
GEO; GSM1374383
GEO; GSM1669585
Polymorphism and mutation databases Cosmic; 724857
Cosmic; 735606
Cosmic; 801570
Cosmic; 844825
Cosmic; 876134
Cosmic; 910851
Cosmic; 917971
Cosmic; 929961
Cosmic; 932914
Cosmic; 933581
Cosmic; 961832
Cosmic; 1006531
Cosmic; 1146870
Cosmic; 1218868
Cosmic; 1239866
Cosmic; 2042862
Cosmic; 2125175
Proteomic databases PRIDE; PXD002556