Cell line name | A-388 | ||||||||||||||||||
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Synonyms | A388 | ||||||||||||||||||
Accession | CVCL_1063 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: A-388 (RRID:CVCL_1063) | ||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. | ||||||||||||||||||
Sequence variations | Heterozygous for EGFR p.Arg832Cys (c.2494C>T) (ClinVar=VCV000936373) (ATCC).Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (ATCC).Heterozygous for TP53 p.Cys135Phe (c.404G>T) (ClinVar=VCV000376559) (ATCC; Cosmic-CLP). | ||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Skin squamous cell carcinoma (NCIt: C4819) Derived from metastatic site: Lymph node. | ||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||
Age at sampling | 86Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): ATCC; Cosmic-CLP Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Publications | PubMed=4357758; DOI=10.1093/jnci/51.5.1417 PubMed=327080; DOI=10.1093/jnci/59.1.221 PubMed=833871; DOI=10.1093/jnci/58.2.209 PubMed=375235; DOI=10.1073/pnas.76.3.1288 PubMed=6256643; DOI=10.1038/288724a0 PubMed=22282976; DOI=10.1093/carcin/1.1.21 PubMed=6954533; DOI=10.1073/pnas.79.7.2194 PubMed=3518877; DOI=10.3109/07357908609038260 PubMed=1358434 PubMed=20164919; DOI=10.1038/nature08768 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line collections | ATCC; CRL-7905 | ||||||||||||||||||
Cell line databases/resources | CCLE; A388_SKIN
Cell_Model_Passport; SIDM00794 Cosmic-CLP; 910697 DepMap; ACH-001442 LINCS_LDP; LCL-1342 | ||||||||||||||||||
Ontologies | CLO; CLO_0001584 | ||||||||||||||||||
Biological sample resources | BioSample; SAMN03471118 | ||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308159
ChEMBL-Targets; CHEMBL2366355 GDSC; 910697 PharmacoDB; A388_43_2019 | ||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-3610
GEO; GSM1669583 | ||||||||||||||||||
Other | Wikidata; Q54606033 | ||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 688037
Cosmic; 910697 Cosmic; 1995333 IARC_TP53; 21164 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||
Last entry update | 29-Oct-2020 | ||||||||||||||||||
Version number | 26 |