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Cellosaurus ACN (CVCL_1068)

[Text version]

Cell line name ACN
Accession CVCL_1068
Resource Identification Initiative To cite this cell line use: ACN (RRID:CVCL_1068)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 9588; PTEN; Simple; p.Asn184fs*6 (c.545_546insA); Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 11998; TP53; Simple; p.Phe113Ser (c.338T>C); ClinVar=VCV000823709; Zygosity=Homozygous (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.3
Native American0.69
East Asian, North0
East Asian, South0.16
South Asian1.02
European, North70.67
European, South27.16
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y3M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ICLC

Markers:
AmelogeninX
CSF1PO10,11 (ICLC)
11 (Cosmic-CLP)
D5S81811,12 (ICLC)
12 (Cosmic-CLP)
D7S82010,13
D13S31711,13
D16S53910,11 (ICLC)
11 (Cosmic-CLP)
D21S1128
TH018,9 (ICLC)
9 (Cosmic-CLP)
TPOX9,12
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=2467885; DOI=10.1002/ijc.2910430421
Gross N., Beck D., Portoukalian J., Favre S., Carrel S.
New anti-GD2 monoclonal antibodies produced from gamma-interferon-treated neuroblastoma cells.
Int. J. Cancer 43:665-671(1989)

PubMed=1354203; DOI=10.1002/ijc.2910520116
Gross N., Favre S., Beck D., Meyer M.
Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants.
Int. J. Cancer 52:85-91(1992)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ICLC; HTL96020
Cell line databases/resources CLDB; cl239
CCLE; ACN
Cell_Model_Passport; SIDM00057
Cosmic-CLP; 906803
DepMap; ACH-002389
LINCS_LDP; LCL-1982
Ontologies CLO; CLO_0001655
Chemistry resources ChEMBL-Cells; CHEMBL3308148
ChEMBL-Targets; CHEMBL2366195
GDSC; 906803
PharmacoDB; ACN_55_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669594
Other Wikidata; Q54608539
Polymorphism and mutation databases Cosmic; 906803
IARC_TP53; 21170
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number27